11-a-Hydroxy canrenone methyl ester Basic information
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Product Name: |
11-a-Hydroxy canrenone methyl ester |
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Synonyms: |
11-a-Hydroxycanrenonemethylester;11-ALPHA-HYDROXY-7-ALPHA-(METHOXYCARBONYL)-3-OXOPREGN-4-ENE-21,17-ALPHA-CARBOLACTONE;(7α,11α,17α)-11,17-Dihydroxy-3-oxopregn-4-ene-7,21-dicarboxylicAcidγ-LactoChemicalbookneMethylEster;11α,17β-Dihydroxypregn-4-en-3-one7α,21-dicarboxylicAcidγ-LactoneMethylEster;11α-HydroxyMexrenone;11α-HydroxyMexrenone;11-Alpha-Hydroxycanrenonemethylester;EplerenoneintermediateA2 |
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CAS: |
192704-56-6 |
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MF: |
C24H32O6 |
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MW: |
416.51 |
11-a-Hydroxy canrenone methyl ester Chemical Properties
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Boiling point |
604.5±55.0 °C(Predicted) |
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density |
1.27±0.1 g/cm3(Predicted) |
| Storage conditions | Sealed in dry,Room Temperature |
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pka |
14.40±0.70(Predicted) |
11-a-Hydroxy canrenone methyl ester is an eplerenone impurity
Eplerenone
Indications: Used for primary hypertension and heart failure after myocardial infarction. For severe hypertension that cannot be controlled by combining multiple antihypertensive drugs, the addition of eplerenone can significantly reduce blood pressure, especially the systolic blood pressure. Combined treatment with angiotensin converting enzyme inhibitory factor (ACEI) and β-blocker can improve the quality of life and reduce mortality of patients with severe heart failure and myocardial infarction.
A good medicine for treating high blood pressure has a protective effect on the liver, heart, and kidneys without damaging the organs. This medicine can promote urination without losing potassium.
Pharmacological effects:
EPL is a selective aldosterone receptor antagonist, it only acts on mineralocorticoid receptors, not on androgen and progesterone receptors. EPL treatment of patients with hypertension in stage 1 and stage 2 is similar to enalapril in the effectiveness and reduction of systolic and diastolic blood pressure. EPL also has a good antihypertensive effect in patients with essential hypertension with low renin levels and angiotensin-converting enzyme inhibitors and angiotensin receptor inhibitors. It also has a good antihypertensive effect on simple systolic hypertension, and has a good antihypertensive effect on diet-related obesity-related hypertension. In addition, EPL can significantly reduce the glomerular ultrafiltration effect, can reduce the albuminuria of hypertensive patients, for hypertensive patients with diabetes, this renal protection effect is more obvious
efficacy:
1. Congestive heart failure after acute myocardial infarction: Eplerenone can improve the quality of life of patients with left ventricular dysfunction (ejection fraction ≤40%), clinical trials have shown that this product can also be used for heart failure after acute myocardial infarction Congestive heart failure after acute myocardial infarction;
2. Antihypertensive: Eplerenone can be used alone or in combination with other antihypertensive drugs for the treatment of hypertension.
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