Anti-hyperlipidemic drugs are a key means of dealing with abnormal blood lipid levels. These drugs mainly act on the human body's lipid metabolism process to regulate the lipid levels in the blood. They can reduce elevated cholesterol and triglycerides, adjust the proportion of lipoproteins, thereby reducing blood viscosity and improving blood circulation. In clinical applications, anti-hyperlipidemic drugs can effectively reduce the risk of cardiovascular diseases such as myocardial infarction and stroke. They are an important line of defense in the prevention and treatment of hyperlipidemia and its complications, helping to maintain the health of the human cardiovascular system.
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(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane...MF:C14H23NO4. MW:269.34. EINECS:425-780-3.
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Tert-butyldimethylsilyl Chloride CAS NO.18162-48-6Silane reagents; coupling reagents; organometallic reagents; condensation reagents; silicon compounds; chlorosilanes; protected amino acids; silane reagents; protection and derivatization;
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N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine...Although Z8-2 is not as popular as the intermediate in the first few steps, it is also an indispensable intermediate. In recent years, the market demand for Z8-2 is gradually expanding, and it has
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Rosuvastatin Calcium Intermediate D5 CAS NO.154026-95-6Pharmaceutical intermediates; rosuvastatin calcium intermediates; synthetic material intermediates
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Atorvastatin Hemicalcium Trihydrate CAS NO.344423-98-9CAS: 344423-98-9. MF: C66H74CaF2N4O13. MW: 1209.3875664
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Atorvastatin Calcium CAS NO.134523-03-8MF: C66H68CaF2N4O10. MW: 1155.36. EINECS: 200-659-6
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Rosuvastatin Calcium CAS NO.147098-20-2MF: C44H54CaF2N6O12S2. MW: 1001.14. EINECS: 627-028-1
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Methyl Isobutyrylacetate (MIBA) CAS NO.42558-54-3MF: C7H12O3. MW: 144.17. EINECS: 418-900-0
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Atorvastatin Acetonide tert-Butyl Ester CAS NO. 125971-95-1MF: C40H47FN2O5. MW: 654.81. EINECS: 258-925-2
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3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinolin...MF: C19H15BrFN. MW: 356.23. EINECS: 686-743-7
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[2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-tr...MF: C37H30BrFNP. MW: 618.5169642. EINECS: 1312995-182-4
Classification of Anti-hyperlipidemic Drugs
Anti-hyperlipidemic drugs can be mainly classified into the following categories
Statins:
They reduce cholesterol synthesis by inhibiting HMG - CoA reductase and increase the expression of LDL receptors at the same time. They have a strong effect on reducing LDL - C.
Fibrates:
They activate PPARα and enhance the activity of LPL, significantly reducing TG and slightly increasing HDL - C.
Niacins:
They inhibit lipolysis in adipose tissue and reduce the synthesis of VLDL in the liver, comprehensively regulating lipoprotein metabolism.
Bile acid sequestrants:
They bind to bile acids in the intestine and promote the excretion of bile acids. This leads to an increased conversion of cholesterol to bile acids in the liver, thereby reducing blood cholesterol levels.
Cholesterol absorption inhibitors:
They inhibit the cholesterol transport protein in the small intestine, reducing the absorption of cholesterol in the intestine.
Others:
For example, PCSK9 inhibitors reduce LDL - C by inhibiting the PCSK9 protein and increasing the number of LDL receptors.
FAQ
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N O Bis trimethylsilyl acetamide, CAS NO 71 30 7, N O Bis trimethylsilyl trifluoro acetamide