Tert-butyldimethylsilyl chloride Basic information
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Product Name: |
Tert-butyldimethylsilyl chloride |
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Synonyms: |
t-butylchlorodimethyl-silan;SILANE TBM2;SILANE, CHLORO(1,1-DIMETHYLETHYL)DIMETHYL-;T-BUTYLDIMENHYLSILYL CHLORIDE;t-butyl dimethyl chlorsilane;T-BUTYLDIMETHYLCHLOROSILANE;T-BUTYLDIMETHYLSILYL CHLORIDE;TBDMSCI |
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CAS: |
18162-48-6 |
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MF: |
C6H15ClSi |
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MW: |
150.72 |
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EINECS: |
242-042-4 |
Tert-butyldimethylsilyl chloride Chemical Properties
| Melting point | 86-89 °C (lit.) |
| Boiling point | 125 °C (lit.) |
| density | 0.87 g/mL at 20 °C(lit.) |
| vapor pressure | 60-710Pa at 25℃ |
| refractive index | n20/D 1.46 |
| Fp | 73 °F |
| storage temp. | Store below +30°C. |
| solubility | very sol nearly all common organic solvents such as THF, methylene chloride, and DMF. |
| form | white solid |
| Specific Gravity | 1.225 |
| color | white |
| Water Solubility | Soluble in chloroform and ethyl acetate. Insoluble in water. |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| Sensitive | Moisture Sensitive |
| BRN | 505999 |
Tert-butyldimethylsilyl chloride Usage And Synthesis
| Chemical Properties | tert-Butyldimethylsilyl chloride is a colorless or white solid that is soluble in many organic solvents but reacts with water and alcohols.It is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids. |
| Uses | tert-Butyldimethylchlorosilane is used to protect hydroxyl group in organic synthesis. It finds application in the synthesis of prostaglandin. It is also used as an auxiliary material for hypolipaemics such as lovastatin and simvastatin. It plays an important role in the preparation of isoxazolines N-oxides from alpha-bromonitroalkanes. It acts as a versatile protecting reagent for amines, amides and alcohols. |
Used as a pharmaceutical intermediate and in organic synthesis, as a hydroxyl protecting agent in organic synthesisUsed to synthesize prostaglandins, certain antibiotics, the auxiliary material of lovastatin and simvastatin for lowering blood lipids
Used in pharmaceutical intermediates and organic synthesis, it is a sterically hindered silicone protective agent, widely used in the synthesis of original drugs. Used as a protective group for hydroxyl in the synthesis of ribonucleosides, as well as an oxidizing agent and decyanation agent
Silanizing agent. In organic synthesis, it is used as hydroxyl protecting agent and derivatization reagent for analysis and preparation. Protect tertiary alcohols. Reacts with alcohols to form silicon ethers. Determine the conformation of cholesterol derivatives. Synthetic prostaglandin
Synthesis method: Cool the pentane solution of dichlorodimethylsilane to 0°C, and add the pentane solution of tert-butyl lithium dropwise under nitrogen and stirring. Maintained at 0°C, stirred and reacted for 1.5 hours, then heated to 25°C, and continued to react for 48 hours. Distillation, collect 125 ℃ (97.5kPa) distillate, stand to solidify, obtain tert-butyl dimethyl chlorosilane. 70% yield
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