What is Ensifentrine Intermediate?
Ensifentrine intermediate is a key pharmaceutical intermediate for synthesizing the novel respiratory drug Ensifentrine, and it belongs to the category of raw materials for respiratory drugs. Its core structure contains a pyrimido[6,1-a]isoquinoline parent nucleus, with typical representatives including compounds such as 9,10-dimethoxy-2-(2,4,6-trimethylphenylimino)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one (SM raw material).
As the core building block for Ensifentrine synthesis, this type of intermediate undergoes steps such as reaction with cyclohexylamine under basic conditions, followed by condensation with urea to construct the target drug molecule; the yield of these two-step reactions can reach over 67%. Its purity must be above 99%, which is critical to ensuring the efficacy, safety, and stability of industrial production of the final drug. With the expanding application of Ensifentrine in the treatment of chronic obstructive pulmonary disease (COPD), the market demand for such high-purity intermediates continues to grow, and they are widely used in active pharmaceutical ingredient (API) production and process optimization by pharmaceutical enterprises.
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CAS：75535-95-4 1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-pyrimid...CAS No. 75535-95-4MF C₁₄H₁₆N₂O₅MW 292.29
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