CAS:75535-95-4 1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-pyrimidine-2,4,6-trione

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CAS:75535-95-4 1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-pyrimidine-2,4,6-trione
Details
CAS No. 75535-95-4
MF C₁₄H₁₆N₂O₅
MW 292.29
Category
Ensifentrine Intermediate
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Description
Name
1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-pyrimidine-2,4,6-trione
Synonyms
1-(2-(3,4-Dimethoxy phenyl)pyrimidin-2,4,6(1H,3H,5H)-trion; 
4-nitrophenyl decanoyl-L-phenylalaninate;
1-[2-(3,4-dimethoxyphenyl)ethyl]-1,3-diazinane-2,4,6-trione - [AC80874];
1-(3,4-Dimethoxyphenethyl)Pyrimidine-2,4,6(1H,3H,5H)-triketone
CAS No.
75535-95-4
MF
C₁₄H₁₆N₂O₅
MW
292.29
Density:
1.274±0.06 g/cm³ (Predicted)
Acidity coefficient (pKa): 5.03±0.40 (Predicted)
Usage

Supporting drug R&D in specific fields: It serves as a key basic raw material in pharmaceutical research and development. The pyrimidine trione ring contained in its structure is a classic pharmacophore for drugs in fields such as antiepileptics and sedative-hypnotics, while the dimethoxyphenethyl group in the structure can regulate the lipophilicity of the compound, thereby improving its binding ability to drug targets. However, it has no direct therapeutic activity itself; after subsequent functional group transformation and structural optimization, it can become the R&D foundation for such drugs with clear pharmacological effects.

Acting as a basic intermediate in organic synthesis: In the field of organic synthesis, it can undergo derivatization reactions through its structural characteristics. On one hand, the active hydrogen atoms on the pyrimidine trione ring, and on the other hand, the substituents on the benzene ring, can both serve as reaction sites for derivatization operations. This helps researchers construct more complex organic compounds, providing key intermediate products for the subsequent synthesis of various fine chemicals or novel compounds.

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