What are selpercatinib intermediates?
Selpercatinib intermediates refer to key chemical precursors and intermediate products used in the synthesis of selpercatinib (LOXO292), a highly selective RET kinase inhibitor. Selpercatinib is mainly used to treat tumors such as non-small cell lung cancer and medullary thyroid cancer harboring RET fusions or mutations, and its synthesis relies on intermediates for core structure construction.
These intermediates mostly contain characteristic heterocyclic scaffolds like pyrazolo[1,5-a]pyridine, along with active functional groups including bromine atoms, methoxy groups, and cyano groups. Their core roles are building the drug's core pharmacophore, introducing key structural fragments, and achieving selective functional group transformations.
As a crucial bridge connecting basic chemical raw materials and the final drug, they directly affect the efficiency, product purity, and stereoselectivity of the synthetic route. They are vital for ensuring the quality, efficacy, and safety of selpercatinib, and are indispensable in the R&D and industrial production of targeted antitumor drugs.
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CAS：1207836-10-9 6-bromo-4-methoxypyrazolo[1,5-a]pyridine...CAS 1207836-10-9MF C₉H₆BrN₃OMW 252.07
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CAS NO 191732 72 6, Atazanavir Intermediates, Lenalidomide
