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Name
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6 - bromo - 4 - methoxypyrazolo[1,5 - a]pyridine - 3 - carbonitrile
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Synonyms
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LOXO - 292 Intermediate;
6 - bromo - 4 - methoxypyrazolo[1,5 - a]pyridine - 3 - carbonitrile;
6 - Bromo - 4 - methoxypyrazol; ol[1,5 - a]pyridine - 3 - carbonitrile;
Pyrazolo[1,5 - a]pyridine - 3 - carbonitrile, 6 - bromo - 4 - methoxy - ;
6 - bromo - 4 - methoxypyrazole[1,5 - a]pyridine - 3 - carbonitrile;
6 - bromo - 4 - methoxypyrazolol[5 - alpyridine - 3 - carbonitrile;
6 - Bromo - 4 - methoxypyrazolo[1,5 - A]pyridine - 3 - acetonitrile
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CAS
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1207836-10-9
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MF
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C₉H₆BrN₃O
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MW
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252.07
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EINECS
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210 - 745 - 2
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Density
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1.67±0.1 g/cm³ (Predicted)
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Storage Conditions
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Sealed in dry, Room Temperature
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pKa
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-1.97±0.30 (Predicted)
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Form
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Solid
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Usage
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1. Core Intermediate for Targeted Drug Synthesis
As a key precursor of selpercatinib (LOXO292), its cyano group and heterocyclic scaffold are core fragments for constructing the core pharmacophore of RET kinase inhibitors, supporting the industrial production of targeted antitumor drugs.
2. Structural Modification Raw Material for Heterocyclic Drug R&D
The cyano group can be converted into carboxylic acid, amine and other functional groups through hydrolysis, reduction and other reactions. Combined with the coupling reaction activity of bromine atoms, it is used to synthesize various kinase inhibitors, facilitating the R&D of antitumor and anti-inflammatory drugs.
3. Key Building Block in Organic Synthesis
With the dual structural characteristics of pyrazolo[1,5-a]pyridine heterocycle and cyano group, it serves as a specialized building block in fine organic synthesis. It is used to construct novel nitrogen-containing heterocyclic compounds, providing a structural basis for pharmaceutical chemistry, materials chemistry and other fields.
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