1156491-10-9 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine Hydrochloride

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1156491-10-9 (1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine Hydrochloride
Details
Category
Ticagrelor & Ticagrelor Intermediate
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Description
Name
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride
Synonyms
(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine Hydrochloride(1:1);(1R,2S)-2-(3,4-Difluorophenyl)- cyclopropan-1-amine HCl;(1R trans)-2-(3,4-difluorophenyl)cyclopropanamine hydrochloride;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine;2-(3,4-Difluoro-phenyl)-cyclopropylamine;(1R trans)-2-(3,4-Difluorophenyl)cyclopropane amine;(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride;CYCLOPROPANAMINE, 2-(3,4-DIFLUOROPHENYL)-, HYDROCHLORIDE (1:1), (1R,2S)-REL-
CAS 
1156491-10-9
MF
C9​H10​ClF2​N
MW
205.63
EINECS 
829-852-9
Melting Point
>172°C (dec.)
Storage Conditions
Inert atmosphere, Store in freezer, under -20°C
Solubility
Slightly soluble in DMSO, slightly soluble in methanol
Form
Solid
Color
White
Usage

1.Serve as a key intermediate in antidepressant drug research and development, used to synthesize cyclopropylamine compounds with specific stereoconfigurations that may act on neurotransmitter transporters to exert activity.

2.Applied in the structural modification of selective serotonin reuptake inhibitor (SSRI) drugs, optimizing the lipophilicity, bioavailability, and targeting of drugs by introducing 3,4-difluorophenyl and cyclopropylamine skeletons.

3.Function as a standard reagent in medicinal chemistry research, used to verify the feasibility of new synthetic routes or as a reference substance in drug metabolism and pharmacological activity screening experiments.

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