CAS:145783-15-9 4,6-dichloro-2-propylthiopyrimidine-5-amine

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CAS:145783-15-9 4,6-dichloro-2-propylthiopyrimidine-5-amine
Details
CAS  145783-15-9
MF C7H9Cl2N3S
MW 238.14
EINECS  808-051-8
Category
Ticagrelor & Ticagrelor Intermediate
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Description
Name
4,6-dichloro-2-propylthiopyrimidine-5-amine
Synonyms

4,6-dichloro-2-propylthiopyrimidine-5-amine;

4,6-dichloro-2-(propylthio)-5-PyriMidinaMine;

4,6-Dichloro-2-(propylthio)pyrimidin-5-amine;

Tecagrelor InterMediate 3;

5-Pyrimidinamine, 4,6-dichloro-2-(propylthio)-;

4,6-dichloro-2-(propylsulfanyl)-5-pyrimidinamine;

4,6-Dichloro-5-amino-2-propylthiopyrimidine

CAS 
145783-15-9
MF
C7H9Cl2N3S
MW
238.14
EINECS 
808-051-8
Boiling Point
334.1±37.0 °C (Predicted)
Density
1.44
Storage Conditions
Keep in dark place, Sealed in dry, Room Temperature
Solubility
Soluble in methanol
Form
Powder to lumpy to transparent liquid
Acid - dissociation Constant (pKa)
-3.46±0.12 (Predicted)
Color
White or colorless to brown
Water Solubility
100mg/L at 22℃
Usage
Pharmaceutical Intermediate:It is a key intermediate for the anti - platelet drug Ticagrelor (brand names Brilinta®/Brilique®). Ticagrelor is a P2Y12 receptor inhibitor used to prevent blood clots in patients with acute coronary syndrome (ACS) or myocardial infarction (MI), and this compound is used in the synthesis process of Ticagrelor's active pharmaceutical ingredient (API).
Organic Synthesis and Pharmaceutical R & D:It serves as a useful building block in the research and development of anti - thrombotic drugs and related heterocyclic compounds. It is also employed in laboratory - scale synthesis and process optimization for the development of new drugs in the field of cardiovascular diseases.

 

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