Isosorbide 5-mononitrate Basic information
|
Product Name: |
Isosorbide 5-mononitrate |
|
Synonyms: |
IMDUR;IS-5-MN;ISOSORBIDE MONONITRATE;ISOSORBIDE 5-MONONITRATE;ISOSORBIDE 5-NITRATE;ELANTAN;ELAN;CORANGIN |
|
CAS: |
16051-77-7 |
|
MF: |
C6H9NO6 |
|
MW: |
191.14 |
|
EINECS: |
240-197-2 |
Isosorbide 5-mononitrate Physical and Chemical Properties
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Melting point |
88-93 °C |
| Alpha | 170 º (c=1, EtOH) |
|
Boiling point |
326.86°C (rough estimate) |
| Density | 1.5784(rough estimate) |
| Refractive index | 145 ° (C=5, H2O) |
|
Storage Condition |
-20°C Freezer |
| pka | 13.09±0.40(Predicted) |
|
Form |
Solid |
| Color | White to Off-White |
| Merck | 5225 |
|
Solubility |
Undiluted isosorbide mononitrate is freely soluble in water, in acetone, in ethanol (96 per cent) and in methylene chloride. The solubility of the diluted product depends on the diluent and its concentration. |
Isosorbide 5-mononitrate Usage
| Chemical Properties | white to light yellow crystal powde |
|
Uses |
Isosorbide 5-Mononitrate is a metabolite of Isosorbide Dinitrate; used as an antianginal.antidepressant, 5HT reuptake inhibitor.A metabolite of Isosorbide Dinitrate. Used as an antianginal |
Pharmacology
This product binds to sulfhydryl groups in vascular smooth muscle and cells to produce NO or S-nitrosothiol compounds, both of which can activate guanylate cyclase, increase cyclic guanylate (cGMP), and accelerate calcium ions from the cell When released, Chemicalbook inhibits the influx of calcium ions, reduces calcium ions in cells, and relaxes vascular smooth muscle. The vasodilation effect of 5-isosorbide mononitrate is dose-dependent. As the dose increases, venous blood vessels, coronary arteries and resistance arterioles are sequentially expanded.
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