Gemcitabine Base information
|
Product Name: |
Gemcitabine |
|
Synonyms: |
GEMCITABINE HCL USP;2'-Deoxy-2',2'-difluoro-D-cytidine;2''-DEOXY-2'',2''-DIFLUOROCYTIDINE(GEMCITABINE);2',2'-Difluorodeoxycytidine;Cytidine, 2'-deoxy-2',2'-difluoro-;gemicitabine;NSC 613327;gencitabine base |
|
CAS: |
95058-81-4 |
|
MF: |
C9H11F2N3O4 |
|
MW: |
263.2 |
|
EINECS: |
619-100-6 |
Gemcitabine Chemical Properties
|
Melting point |
168,64 C |
| alpha | 365 +425.36°; D +71.51° |
| Boiling point | 482.7±55.0 °C(Predicted) |
| density | 1.84±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | Methanol (Slightly), Water (Slightly, Heated) |
| pka | 11.65±0.70(Predicted) |
| form | Solid |
|
color |
White to Off-White |
Gemcitabine Usage And Synthesis
|
Uses |
Gemcitabine(Gemzar) belongs to the group of medicines called antimetabolites. It is used alone or in combination with other medicines to treat cancer of the breast, ovary, pancreas, and lung. Gemcitabine is used for breast cancer treatment. First-line treatment for locally advanced pancreatic cancer. |
Gemcitabine Specification
|
Characters |
White or almost white |
|
Identification |
IR spectrum shall comply |
|
Cytosine |
Not more than 0.1% |
|
α-isomer |
Not more than 0.1% |
|
Unspecified |
Not more than 0.1% |
|
Related |
Not more than 0.2% |
|
Water |
Not more than 1.0% |
|
Sulphated ash |
Not more than 0.1% |
|
Heavy metals |
Not more than 10ppm |
|
Assay |
97.5%~101.5%, calculated |
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