Ceftriaxone sodium Basic information
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Product Name: |
Ceftriaxone sodium |
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Synonyms: |
CEFATRIAXONE;2,5,6-tetrahydro-2-methyl-5,6-dioxo-)(methoxyimino)acetyl)amino)-8-oxo-3-(((;4-triazin-3-yl)thio)methyl)-,sodiumsalt,hydrate(2:4:7)(6r-(6-alpha,7-2;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, disodium salt, [6R-[6α,7β(Z)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, disodium salt, (6R,7R)-;Ceftriaxone disodium;Longaceph;Ceftriaxonesodiumnon-steriled |
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CAS: |
74578-69-1 |
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MF: |
C18H16N8Na2O7S3 |
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MW: |
578.57 |
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EINECS: |
277-930-0 |
Ceftriaxone sodium Chemical Properties
| storage temp. | 4°C, protect from light |
| Water Solubility | Water : ≥ 40 mg/mL (66.60 mM) |
Ceftriaxone sodium Usage And Synthesis
| Description | Ceftriaxone is a cephalosporin (SEF a low spor in) antibiotic that is used to treat conditions such as lower respiratory tract infections, skin and skin structure infections, urinary tract infections, pelvic inflammatory disease, bacterial septicemia, bone and joint infections, and meningitis. |
| Originator | Rocephin,Roche,Switz.,1982 |
| Uses | Ceftriaxone sodium is antibacteria,an impurity of Ceftriaxone (C244995). It is an antibacterial, a third-generation cephalosporin. |
| Brand name | Rocephin (Roche). |
| Therapeutic Function | Antibacterial |
| Veterinary Drugs and Treatments | Ceftriaxone is used to treat serious infections, particularly against susceptible Enterobacteriaceae that are not susceptible to other less expensive agents or when aminoglycosides are not indicated (due to their potential toxicity). Its long half life, good CNS penetration, and activity against Borrelia burgdorferi also has made it a potential choice for treating Lyme's disease. |
Ceftriaxone sodium Specification
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Description |
White to yellowish-orange crystalline powder |
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Identification |
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Solubility |
Freely soluble in water, sparingly soluble in |
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Crystallinity |
It shows birefringence and extinction positions. |
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pH |
6.0-8.0 |
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Water |
8.0%-11.0% |
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Organic impurities |
Deacetylcefotaxime lactone ≤0.5% |
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7-Aminocephalosporanic acid ≤0.5% |
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Ceftriaxone triazine analog ≤1.0% |
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Ceftriaxone benzothiazolyl oxime ≤0.2% |
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Deacyl ceftriaxone ≤0.5% |
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Ceftriaxone 3-ene isomer ≤0.3% |
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Ceftriaxone E-isomer ≤0.5% |
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Any individual unspecified impurity ≤0.2% |
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Total impurity?≤2.5% |
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Sterility |
Meets the specifications |
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Bacterial endotoxins |
＜0.20EU/mg |
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Appearance of solution |
The solution is clear and not more intensely |
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Particulate matter |
≥10µm:?≤6000pc/g |
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≥25µm: ≤600pc/g |
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Residue solvent |
Acetone≤?5000ppm |
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Bulk density |
Reference item |
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Tapped density |
Reference item |
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Absorbance at 430nm |
Reference item |
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Flow index |
Reference item |
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Assay |
It contains the equivalent of NLT 795µg/mg |
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