Diclofenac Sodium Basic Information
|
ProductName |
Diclofenac Sodium |
|
Synonyms |
N-(2,6-Dichlorophenyl)-o-aminophenylacetic acid sodium salt;sodium(o-((2,6-dichlorophenyl)amino)phenyl)acetate;sodium(o-(2,6-dichloroanilino)phenyl)acetate;sodiumdiclofenac;tsudohmin;AKOS B020028;2-(2,6-DICHLOROANILINO)PHENYLACETIC ACID SODIUM SALT;2-[(2,6-DICHLOROPHENYL)AMINO]-BENZENEACETIC ACID MONOSODIUM SALT |
|
CAS |
15307-79-6 |
|
MF |
C14H10Cl2NNaO2 |
|
MW |
318.13000 |
| EINECS | 239-346-4 |
Diclofenac Sodium chemical properties
|
Melting point |
288-290°C |
| density | 0.781 g/cm3 |
|
Storage temp. |
room temp |
| Solubility | H2O: 50 mg/mL |
| pka | 4(at 25℃) |
|
Form |
White solid |
| color | White to Almost white |
| Water Solubility | Soluble in water to 50mg/ml. |
| Merck | 14,3081 |
| BCS Class | 2 |
|
Stability |
Stable |
Diclofenac Sodium Usage And Synthesis
| Description | Diclofenac Sodium is the sodium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac sodium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. |
| Uses | Diclofenac is a phenylacetic acid derivative belonging to the class of the non-selective non-steroidal anti-inflammatory drugs (NSAIDs). It exhibits analgesic, antipyretic and anti-inflammatory activity. Due to its poor solubility, the parenteral formulation of diclofenac sodium (Voltarol ampoules) currently available in Europe contains the solvents propylene glycol and benzyl alcohol that allows intramuscular and intravenous administration. Diclofenac sodium has long been used to treat acute pain and inflammation, and is effective in various acute forms of pain. |
Its anti-inflammatory effect is 2-2.5 times that of indomethacin and 26-50 times stronger than acetylsalicylic acid. It is suitable for rheumatoid arthritis, osteoarthritis, postoperative pain relief and fever caused by various reasons. Also a standard NSAID and cyclooxygenase (COX) inhibitor; a selective substrate for CYP2C9
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