Dapoxetine hydrochloride Basic information
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Product Name: |
Dapoxetine hydrochloride |
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Synonyms: |
DL-Dapoxteine HCL;N,N-DiMethyl-1-phenyl-3-(1-naphthalenyloxy)propanaMinehydrochloride;(S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine hydrochloride;Dapoxetine/Dapoxetine HCl/Dapoxetine hydrochloride;LY-210448 hydrochloride;Priligy;PRILIGY;LY-210448 HYDROCHLORIDE |
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CAS: |
129938-20-1 |
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MF: |
C21H24ClNO |
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MW: |
341.88 |
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EINECS: |
640-411-8 |
Dapoxetine hydrochloride Chemical Properties
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Melting point |
175-1790C |
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alpha |
D +135.78° (c = 2.18 in methanol) |
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storage temp. |
room temp |
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solubility |
DMSO: ≥20mg/mL |
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form |
powder |
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color |
white |
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optical activity |
[α]/D +125 to +135°, c = 1 in methanol |
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Merck |
14,2821 |
Dapoxetine hydrochloride Usage And Synthesis
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Chemical Properties |
Dapoxetine hydrochloride is a white to slightly yellow powder. It is freely soluble in methanol, propylene glycol, some organic solvents (eg. N,N-dimethylformamide) , slightly soluble in ethanol and almost insoluble in water. It is a BCSI class II compound, and poor solubility is a key factor affecting the difference in clinical efficacy. Dapoxetine hydrochloride exists in various crystal forms, the solubility of different crystal forms is quite different, and there is a phenomenon of phase and transformation between crystal forms. |
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Uses |
Dapoxetine hydrochloride is a short-acting novel selective serotonin reuptake inhibitor marketed for the treatment of premature ejaculation in men. Premature ejaculation (PE) is the most common male sexual disorder, estimated to affect up to 30% of men. |
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