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Details
MF: C40H47FN2O5
MW: 654.81
EINECS: 258-925-2
Category
Atorvastatin Intermediates
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Description

Atorvastatin Acetonide tert-Butyl Ester Basic information

Product Name:

Atorvastatin Acetonide tert-Butyl Ester

Synonyms:

(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-ISOPROPYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROL-1-YL]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE;(4R-CIS)-[1,1-DIMETHYLETHYL-6-[(2-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-YL]ETHYL]-2, 2-DIMETHYL-1, 3-DIOXANE-4-ACETATE;(4R-CIS)-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROL-1-YL]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETIC ACID, 1,1-DIMETHYLETHYL ESTER;L-1(4R-Cis)-1,1-DiMethylethyl-6- 2- 2-(4-Fluorophenyl)-5-(1-Isopropyl)-3-Phenyl-4 (PhenylaMino)carbonyl -1H-pyrrol-1-yl Ethyl -2,2-DiMethyl-1,3-Dioxane-4-Acetate;tert-butyl (4r,6r)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate;tert-Butyl (4R,6R)-6-[2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1-pyrrolyl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate ;tert-Butyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl];(4R-cis)-1,1-dimethylethyl-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate

CAS:

125971-95-1

MF:

C40H47FN2O5

MW:

654.81

EINECS:

258-925-2

 

Atorvastatin Acetonide tert-Butyl Ester Chemical Properties

Melting point

144-148 °C(lit.)

alpha

6.5 º (c=1, chloroform)

Boiling point  678.0±55.0 °C(Predicted)
density  1.14±0.1 g/cm3(Predicted)
solubility  Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

storage temp.

Refrigerator

pka 13.57±0.70(Predicted)
form  Solid
color  White

optical activity

[α]20/D +6.5°, c = 1 in chloroform

 

Atorvastatin Acetonide tert-Butyl Ester Usage And Synthesis

Chemical Properties

White Solid

Uses

Atorvastatin intermediate.Atorvastatin Acetonide tert-Butyl Ester (Atorvastatin EP Impurity I) is an Atorvastatin intermediate.

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