Dehydroepiandrosterone Basic information
|
Product Name: |
Dehydroepiandrosterone |
|
Synonyms: |
TRANS-DEHYDROANDROSTERONE;PRASTERONE;5-ANDROSTENE-3BETA-OL-17-ONE;5-ANDROSTEIN-3B-OL-17-ONE;5-ANDROSTEN-3BETA-OL-17-ONE;DHEA;DEHYDROEPIANDOSTERONE;DEHYDROEPIANDROSTERONE |
|
CAS: |
53-43-0 |
|
MF: |
C19H28O2 |
|
MW: |
288.43 |
|
EINECS: |
200-175-5 |
Dehydroepiandrosterone Chemical Properties
|
Melting point |
149-151 °C(lit.) |
|
alpha |
12 º (c=2, ethanol 96% 25 ºC) |
|
Boiling point |
370.65°C (rough estimate) |
|
density |
1.0484 (rough estimate) |
|
refractive index |
1.4709 (estimate) |
|
Fp |
9℃ |
|
storage temp. |
Hormones |
| solubility | insoluble in H2O; ≥13.7 mg/mL in DMSO; ≥58.6 mg/mL in ETOH |
| pka | 15.02±0.60(Predicted) |
|
form |
Fine Crystalline Powder |
|
color |
White |
| Water Solubility | 21.8mg/L(23.5 ºC) |
|
Merck |
2871 |
|
BRN |
2058110 |
Dehydroepiandrosterone Usage And Synthesis
|
Chemical Properties |
white fine crystalline powder. There are two crystal forms. Needle-like crystal, melting point 140-141oC; small leaf-like crystal, melting point 152-153oC. Has right-handedness. Soluble in alcohol, ether, benzene, slightly soluble in chloroform, petroleum ether. In case of digitonin to produce precipitation. |
| Uses |
Dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is a major secretory steroidal product of the adrenal gland; secretion progresively declines with aging. May have estrogen-or androgen-like effects depending on the hormonal milieu. Intracellularly converted to androstenedione. It is used in treatment of menopausal syndrome. People living with HIV may be interested in taking DHEA for a variety of reasons, including treatment of depression, increasing bone density, decreasing arterial plaques, improvement of immune function with HIV, increased memory, and increased muscle strength. |
Dehydroepiandrosterone Specification
|
Appearance |
White or almost white, |
|
HPLC |
The principal peak in the chromatogram obtained with the test solution is similar in retention time to Reference standard |
|
Loss on drying |
≤0.5% |
|
Melting point |
147-151℃ |
|
Any impurity |
≤0.5% |
|
Purity |
≥99.0% |
It is used as an intermediate for the manufacture of steroid hormone drugs with anti-aging and protein assimilation effects. Main functions: 1. Delay aging, maintain youthful vitality; 2. Enhance physical fitness, improve mood and sleep, improve memory; 3. Improve sexual function, increase libido; 4. Regulate immune system function, improve body immunity, 5. Weight loss; 6. Adjuvant treatment of diseases
The hormones in the human body each have their own unique functions, which increase and decrease with age. As we get older, both melatonin and androsterone will gradually decrease. Generally speaking, the most important function of melatonin for normal people is to control the physiological clock and maintain the body's natural balance. Generally, people start to secrete a lot of melatonin when they are around 17-20 years old, and the secretion of melatonin decreases year by year. This substance acts when a person is awake and helps us control emotions, memory and learning in the psychological state. In the physiological state, it can strengthen our muscle strength, maintain a good ratio of muscle and fat, and make the body firm and lean. , And help us to synthesize metabolism, stimulate the secretion of growth hormone, and regulate the function of the immune system. But in the evening, the secretion gradually slows down, so the pineal gland will begin to secrete melatonin in large quantities, and there will be subtle fluctuations between the two. So we will feel sleepy at night because of the relationship of melatonin, and need to rest, so that DHEA can have a free time to produce pure hormones, and give us stable mood and energy during the day. It can improve glucose endurance, convert excess body fat into muscle, relieve depression, increase body energy, reduce physical pain in patients with chronic fatigue and fibromyalgia, relieve joint pain, fatigue caused by inflammation and autoimmune diseases, and improve spirit State and provide the body’s overall immune function.
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