Basic information
Product Name: | Guanine |
Synonyms: | 2-AMino-6-hydroxy-1H-purine;9H-Guanine;Valaciclovir EP Impurity A;Guanine Vetec(TM) reagent grade, 99%;6H-Purin-6-one, 2-amino-1,7-dihydro- (9CI);6H-purin-6-one, 2-amino-3,7-dihydro-;Guanine (8CI);InChI=1/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11 |
CAS: | 73-40-5 |
MF: | C5H5N5O |
MW: | 151.13 |
EINECS: | 200-799-8 |
Physical and Chemical Properties
Melting point | >300 °C(lit.) |
Boiling point | 273.11°C (rough estimate) |
Density | 1.4456 (rough estimate) |
Storage temp. | 2-8°C |
| Solubility | 1 M NaOH: 0.1 M at 20 °C, clear, colorless |
| Form | Powder |
| pka | 9.92(at 40℃) |
Appearance | White to cream powder |
| Oder | Oderless |
Water Solubility | practically insoluble |
| Decomposition | 360℃ |
| Merck | 14,4564 |
| BRN | 9680 |
Stability: | Stable. Incompatible with strong oxidizing agents. |
Usage And Synthesis
Uses | It can be used for biochemical studies. It can be used as the intermediates of the antiviral drugs acyclovir. |
It is a purine organic compound, which is made of a pyrimidine ring and an imidazole ring. It is a kind of purine. It is composed of carbon and nitrogen atoms and has a characteristic bicyclic structure. It is combined with cytosine in three Hydrogen bonds. It plays an important role in the organism. Not only can guanine have multiple isomers, but it also has the smallest adiabatic ionization potential among the 4 DNA bases. It exists in free or bound state in sea bird droppings. One of the nucleobases exists in both deoxyribonucleic acid and ribonucleic acid.
Modification and expansion of bases can cause cancer or other lesions; accumulation of oxidized bases can easily lead to aging and guanine is the most easily oxidized base, so DNA oxidation usually occurs on guanine bases, guanine ( G) The C8 position is the most susceptible to oxidation, easy to form ring-opening Fapy-G (guanine) and 8-oxo-G (guanine), etc. One of G's damages is Fapy-G formed after opening the loop. It is generally believed that it can prevent DNA synthesis and is cytotoxic, and can be repaired in prokaryotic and eukaryotic cells.
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