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Name
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3 - Morpholino - 1 - (4 - (2 - oxopiperidin - 1 - yl)phenyl) - 5,6 - dihydropyridin - 2(1H) - one
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|---|---|
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Synonyms
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5 - morpholin - 4 - yl - 1 - [4 - (2 - oxopiperidin - 1 - yl)phenyl] - 2,3 - dihydropyridin - 6 - one;
3 - Morpholino - 1 - [4 - (2 - oxo - piperidyl)phenyl] - 5,6 - dihydropyridin - 2(1H) - one;
3 - Morpholino - 1 - (4 - (2 - oxopiperidin - 1 - yl);
Apixaban Impurity H;
Apixaban Intermediates;Apixaban Impurity P;
3 - Morpholin - 4 - yl - 1 - [4 - (2 - oxopiperidin - 1 - yl)phenyl] - 5,6 - dihydro - 1H - pyridin - 2 - one
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CAS No.
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545445 - 44 - 1
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MF
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C₂₀H₂₅N₃O₃
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MW
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355.43
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EINECS No.
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1308068 - 626 - 2
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Melting Point
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>199°C (dec.)
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Boiling Point
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625.0±55.0 °C (Predicted)
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Density
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1.267
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Storage Conditions
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2 - 8°C
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Solubility
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Slightly soluble in chloroform, slightly soluble in methanol
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Form
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Solid
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Acid Dissociation Constant (pKa)
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3.25±0.20 (Predicted)
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Color
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Light beige
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Usage
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Core Intermediate for Apixaban SynthesisIt is a key intermediate in the synthesis of the anticoagulant drug apixaban, used to construct the core main ring structure of apixaban, providing a foundation for the preparation of apixaban API for preventing and treating venous thromboembolism after hip and knee replacement surgery.
Tool for Drug Quality ResearchAs one of the impurities of apixaban, it can be used for impurity analysis, quality control and related research of apixaban drugs, helping to ensure the quality, efficacy and safety of apixaban drugs.
Research ChemicalIt is a useful research chemical, applicable to chemical mechanism research, drug structure optimization and other related scientific research work in pharmaceutical R&D, providing references for the development of new anticoagulant drugs or other related drugs.
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