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Name
|
Trifluoromethanesulfonic acid
|
|
Synonyms
|
Fluorad FC-24; Methanesulfonic acid, trifluoro-; trifluoromethanesulfonic; trifluoro-methanesulfonicaci; FC-24; PERFLUOROMETHANESULFONIC ACID; PFC-MS; TRIFLUOROMETHANESULPHONIC ACID
|
|
CAS No.
|
1493-13-6
|
|
MF
|
CHF₃O₃S
|
|
MW
|
150.08
|
|
EINECS No.
|
216-087-5
|
|
Property
|
Value
|
|---|---|
|
Melting Point
|
-40 °C
|
|
Boiling Point
|
162 °C (lit.)
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|
Density
|
1.696 g/mL at 25 °C (lit.)
|
|
Vapor Density
|
5.2 (vs air)
|
|
Vapor Pressure
|
8 mmHg (25 °C)
|
|
Refractive Index
|
n20/D 1.327 (lit.)
|
|
RTECS Number
|
PB2771000
|
|
Flash Point
|
None
|
|
Storage Conditions
|
Store below +30 °C.
|
|
Solubility
|
Miscible with H2O
|
|
pKa
|
-14 (at 25 °C)
|
|
Form
|
Fuming liquid
|
| Usage |
1. Synthesis of nucleoside antiviral drugs: As a key catalytic reagent, it facilitates the construction of the molecular structure of nucleoside drugs. These drugs can inhibit viral nucleic acid replication and are commonly used in synthesizing the active ingredients of antiviral drugs, such as anti-hepatitis B virus drugs and anti-human immunodeficiency virus (HIV) drugs, ensuring the accurate synthesis of drug molecules to exert antiviral effects. 2. Synthesis of antibiotic anti-infective drugs: It acts as a catalyst in the synthesis of antibiotics (e.g., some penicillin and cephalosporin derivatives), assisting in the construction of the core active structure of antibiotics. It helps synthesize anti-infective drugs that can inhibit bacterial cell wall synthesis or interfere with bacterial metabolism, which are used to treat various infectious diseases caused by bacteria. 3. Synthesis of vitamin drugs: It can catalyze the key synthesis steps of vitamin drugs such as B vitamins (e.g., vitamin B1, vitamin B6) and vitamin D, promoting the structural formation and purification of vitamin molecules. It contributes to the synthesis of vitamin supplementary drugs that maintain the normal physiological functions of the human body, meeting the clinical needs for nutritional supplementation. |
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