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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic Acid CAS NO.:641569-94-0

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4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic Acid CAS NO.:641569-94-0
Details
CAS: 621569-94-0
MF: C17H14N4O2
MW: 306.32
EINECS： 629-968-8
Category
Other Intermediates
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Description
Product Name:
 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
Synonyms:

4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoicacid;NilotinibEPImpurityD;

4-Methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoicacid;Benzoicacid;

4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidinyl]aMino]-;

4-Methyl-3-[[4-(3-pyridinyl)-2-pyriMidiny]aMino]benzoicacid;

2-[(5-Carboxy-2-methylphenyl)amino]-4-(pyridin-3-yl)pyrimidine;

3-{2-[(5-Carboxy-2-methylphenyl)amino]pyrimidin-4-yl}pyridine;

NilotinibIntemediate2;
CAS:
 641569-94-0
MF:
 C17H14N4O2
MW:
 306.32
EINECS： 629-968-8
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
Boiling Point 587.9±60.0 °C(Predicted)
Melting Point >257oC (dec.)
Density 1.336
Acidity Coefficient (pKa) 4.35±0.10(Predicted)
Solubility Soluble in DMSO (slightly), methanol (slightly, with heating)
Form Solid
Color Light beige
Storage temp.
 under inert gas (nitrogen or Argon) at 2–8 °C

Usage

Uses

It is a key intermediate in the synthesis of nilotinib (an antineoplastic drug) and plays an important role in the preparation of nilotinib.

Its structural carboxyl group can be converted to an acyl chloride under the action of thionyl chloride, laying a foundation for subsequent chemical transformations.

The generated acyl chloride can be further converted to an ester group, facilitating the structural construction of relevant drug molecules or derivatives.

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