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5-Fluoro-2-oxindole
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Product Name:
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5-Fluoro-2-oxindole
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Synonyms:
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5-Fluoroindole-2-One;5-Fluoro-1,3-dihydro-indol-2-one;5-FLUORO-2-OXINDOLE;5-FLUORO-2-OXYINDOLE;5-FLUORO-1,3-DIHYDRO-2H-INDOL-2-ONE;5-Fluorooxindole 98%;5-Fluorooxindole98%;5-FLUROOXINDOLE
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CAS:
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56341-41-4
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MF:
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C8H6FNO
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MW:
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151.14
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EINECS:
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638-803-9
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5-Fluoro-2-oxindole
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Melting point
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143-147 °C (lit.)
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Density
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1.311±0.06 g/cm3(Predicted)
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Boiling point
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307.2±42.0 °C(Predicted)
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Apk
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12.99±0.20(Predicted)
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Solubility
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Soluble in chloroform (small amount), methanol (small amount)
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Storage temp.
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Sealed in dry,Room Temperature
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Form
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Powder or crystalline powder
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Color
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White to light brown
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5-Fluoro-2-oxindole Usage
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Uses
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5-fluoroindolin-2-one is an important intermediate in organic synthesis and medicinal chemistry, with its main uses focused on the field of drug synthesis, especially as a key intermediate in the preparation of Sunitinib. Sunitinib is a multi-target tyrosine kinase inhibitor, clinically used in the treatment of gastrointestinal stromal tumors, advanced renal cell carcinoma, etc. Its mechanism of action is to inhibit various receptor tyrosine kinases involved in tumor growth, pathological angiogenesis, and tumor metastasis, thereby exerting anti-tumor effects. In addition, 5-fluoroindolin-2-one can also be used in the synthesis of other bioactive heterocyclic compounds through structural modification, having certain expansion value in drug research and development.
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