Basic information
|
Product Name: |
Cyclosporin A |
|
Synonyms: |
sandimmune;Cyclospori;1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane,cyclicpeptidederiv.;30-Ethyl-33-(1-hydroxy-2-methyl-hex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone;CipolN |
|
CAS: |
59865-13-3 |
|
MF: |
C62H111N11O12 |
|
MW: |
1202.61 |
Physical and chemical properties
|
Melting point |
148-151°C |
|
Boiling point |
838.63°C (rough estimate) |
|
Density |
0.9913 (rough estimate) |
| Flash Point |
87℃ |
|
Appearance |
White powder |
Indications
|
Indications |
It is mainly used for anti rejection of liver, kidney and heart transplantation. It can be used together with adrenocortical hormone, and can also be used for the treatment of some immune diseases |
It is a cyclic polypeptide composed of 11 amino acids. It is an active metabolite of fungi in soil. In 1978, CyA was first used in clinical kidney transplantation in England. Since then, CyA has been used in liver, heart, lung, pancreas, bone marrow and other organs transplantation, which has achieved satisfactory results and significantly improved the survival rate of patients, CyA, as a potent immunosuppressant, can also be used to treat autoimmune diseases, hematologic diseases and anti parasitic diseases.
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