![CAS：1012341-50-2 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic Acid](/uploads/24095/cas-1012341-50-252289.png)
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Name
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(2R,4S)-5-([(1,1'-biphenyl]-4-yl)-4-(tert-butoxycarbonyl)amino)-2-methylpentanoic acid
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Synonyms
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(2R,4S)-5-([(1,1'-biphenyl]-4-yl)-4-(tert-butoxycarbonyl)amino)-2-methylpentanoic acid;
LCZ696 inter; LCZ - 696 - 001 - SS; LCZ696 - 24;
(2R,4S)-5-(4-Biphenylyl)-4-(Boc-amino)-2-methylpentanoic Acid;
(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid AHU84;
(2R,4S)-5-(biphenyl-4-yl)-4-(tert-butoxycarbonyl)amino)-2-methylvaleric acid; LCZ696S - 01
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CAS
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1012341-50-2
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MF |
C₂₃H₂₉NO₄
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MW
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383.48
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EINECS
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1592732-453-0
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Melting Point
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145 - 147°C
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Boiling Point
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582.6±50.0 °C (Predicted)
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Density
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1.115±0.06 g/cm³ (Predicted)
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Storage Conditions
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2 - 8°C
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Solubility
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Slightly soluble in chloroform, slightly soluble in DMSO, slightly soluble in methanol, ultrasonic treatment required for methanol
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Form
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Solid
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Color
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White to off - white
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Usage
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1. (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid is a key synthetic intermediate for the anti-heart failure drug Sacubitril. Its specific chemical structure provides core structural support for the preparation of Sacubitril API, directly affecting the drug's synthesis efficiency and quality stability, and is an indispensable link in industrial production.
2. Its mesylate form is AZD9291 (Osimertinib Mesylate), a tyrosine kinase inhibitor targeting EGFR. It is indicated for adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who have experienced disease progression after prior EGFR-TKI treatment and are confirmed to be EGFRT790M mutation-positive, providing a targeted therapy option for such drug-resistant patients.
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