Paliperidone Palmitate Basic information
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Product Name: |
Paliperidone Palmitate |
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Synonyms: |
(9RS)-3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)et hyl)-2-Methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyriMi din-9-yl hexadecanoate;Hexadecanoic acid 3-[2-[4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]-ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl ester;Paliperidone Palmitate;Paliperidone Palmitate [USAN];Invega Sustenna;RO 92670;9-Hydroxyrisperidone palmitate;Hexadecanoic acid 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl ester |
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CAS: |
199739-10-1 |
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MF: |
C39H57FN4O4 |
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MW: |
664.89 |
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EINECS: |
225-799-5 |
Paliperidone Palmitate Chemical Properties
| Melting point | 110-115°C |
| Boiling point | 736.3±70.0 °C(Predicted) |
| density | 1.19 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly, Heated, Sonicated), Methanol (Slightly) |
| form | Solid |
| pka | 8.07±0.10(Predicted) |
| color | Off-White to Light Beige |
Paliperidone Palmitate Usage And Synthesis
| Description | Paliperidone palmitate is an atypical long acting antipsychotics,which can fast onset in acute phase and continuously improve the symptoms in maintenance phase． It has the solid efficacy and convenient ad[1]ministration,which offer a new option for schizophrenia treatment and will help patients to adhere the treatment and prevent relapse． As the sole long acting antipsychotics with monthly injection,it was approved by CFDA in 2011 and indicated for the acute and maintenance treatment of schizophrenia． |
| Uses | Paliperidone Palmitate is a long-acting injectable atypical antipsychotic used in the treatment of schizophrenia. |
Papperidone palmitate, also known as palmitate, is a long-acting injection of the second-generation antipsychotic, which is mainly used to treat schizophrenia. The active ingredient is paliperidone. Paliperidone palmitate is very low in water solubility. Make paliperidone palmitate into fine particles through nanocrystal wet grinding, improve the water solubility, form a water suspension preparation suitable for intramuscular injection, and increase the absorption rate and bioavailability of the drug.
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