Paliperidone Basic information
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Product Name: |
Paliperidone |
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Synonyms: |
Paliperidone (Invega);3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-Methyl-;Risperidone EP IMpurity C;Paliperidone 9-Hydroxyrisperidone;9-Hydroxyrisperidone solution;Risperidone Impurity 3(Risperidone EP Impurity C);Racemic Paliperidone;Paliperidone (9-Hydroxy Risperidone, Risperidone EP Impurity C) |
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CAS: |
144598-75-4 |
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MF: |
C23H27FN4O3 |
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MW: |
426.48 |
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EINECS: |
620-493-1 |
Paliperidone Chemical Properties
| Melting point | 158-160°C |
| Boiling point | 612.3±65.0 °C(Predicted) |
| density | 1.45±0.1 g/cm3(Predicted) |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble2mg/mL, clear (warmed) |
| pka | 13.00±0.60(Predicted) |
| form | powder |
| color | white to brown |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
Paliperidone Usage And Synthesis
| Descripyion | Paliperidone, (±)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one(Invega), is essentially insoluble in water and is available asextended-release tablets. Paliperidone is delivered at a constantrate using an osmotic drug release device (OsmoticRelease Oral Systems [OROS]). Paliperidone is FDA-approved for schizophrenia aged 12–17. However, the pharmacologic portfolio, extrapolation from adult studies, and the long track record of the parent drug, risperidone in child/adolescent psychiatric (CAP) population might expand its therapeutic potential. |
| Chemical Properties | Off White to Light Orange Coloured Solid |
| Uses | This medication is used to treat certain mental/mood disorders (such as schizophrenia, schizoaffective disorder). This medication can decrease hallucinations and help you to think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life. Paliperidone belongs to a class of drugs called atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain. |
Paliperidone CAS NO.144598-75-4 is a chemical substance, an active metabolite of an atypical antipsychotic drug risperidone, scientific research reagent, widely used in molecular biology, pharmacology and other scientific research. It is also a derivative of benzisoxazole, 9-hydroxyrisperidone, the active metabolite of risperidone, and a new type of antipsychotic drug. Its mechanism of action is still not fully understood. Paliperidone may be related to dopamine D2 and serotonin 2A (5HT2A) is related to its blocking effect. It has a blocking effect on adrenaline α1, α2 and histamine H1 receptors, but has no affinity for choline and adrenaline β1 and β2 receptors. Its left-handed and right-handed bodies are in vitro The pharmacological effects are similar. In addition, it can also increase prolactin levels.
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