Basic information
|
Product Name: |
Loxoprofen sodium |
|
Synonyms: |
alpha-methyl-4-((2-oxocyclopentyl)methyl)benzeneacetatesodiumsaltdihydrate;benzeneaceticacid,alpha-methyl-4-((2-oxocyclopentyl)methyl)-,sodiumsalt,di;cs-600;loxoprofensodium(patented-nosupply);Loxoprofen sodium dihydrate, >=99%;Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate;sodium 2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoate dihydrate;2-{4-[(2-Oxocyclopentyl)methyl]phenyl}propanoic acid sodium salt |
|
CAS: |
80382-23-6 |
|
MF: |
C15H17NaO3 |
|
MW: |
268.283 |
|
EINECS: |
1806241-263-5 |
Physical and Chemical Properties
|
Melting point |
Null |
|
Boiling point |
417.9ºC at 760 mmHg |
|
Storage Condition |
2-8° CInert atmosphere,Room Temperature |
| Flash Point | 220.7℃ |
|
Form |
Null |
|
Solubility |
Null |
Usage
| Descripyion | Loxoprofen sodium i s an antiinflammatory/analgesic agent useful in the management of rheumatoid arthritis and related disorders. It is converted in vivo to the corresponding trans-hydroxycyclopentane analog, through which it appears to exert its activity. |
|
Uses |
Used as an anti-inflammatory and analgesic |
After oral administration of Le Song, it is quickly absorbed in the gastrointestinal tract, and appears in the blood in the form of loxoprofen sodium and anti-OH metabolites (active metabolites), and is distributed in the liver, kidneys, and kidneys in higher concentrations. In the plasma. The peak time after oral administration of 60 mg of Lepine for healthy adults is 30 minutes for the original drug, and about 50 minutes for the active metabolite. The protein binding rate of the original product is 97. Chemicalbook 0%, and the protein binding rate of the active metabolite is 92.8%. Part of the glucuronic acid conjugate or hydroxylated glucuronic acid conjugate is mainly excreted quickly through urine, and about 50% of it is excreted within 8 hours after oral administration. Oral for 5 consecutive days, no accumulation. The half-life of the original product is 1.2h, and the half-life of the active metabolite is 1.3h.
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