Mesalamine Basic Information
| Product Name | Mesalamine |
|
Synonyms |
5-Aminosalicylic acid, 98.5%, IKK inhibitor;2-HYDROXY-5-AMINOBENZOIC ACID;3-Carboxy-4-hydroxyaniline;5-AMINO-2-HYDROXYBENZOIC ACID;5-AMINOSALICYLIC ACID;5-ASA;5-AS;rowasa |
| CAS | 89-57-6 |
| MF | C7H7NO3 |
| MW | 153.135 |
| EINECS | 201-919-1 |
Mesalamine Chemical Properties
| Melting point | 275-280 °C (dec.) (lit.) |
| Boiling point | 276.03°C (rough estimate) |
| density | 1.3585 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5500 (estimate) |
| Fp | 279-281°C |
| storage temp. | 2-8°C |
| solubility | Soluble in dimethyl sulfoxide. |
| pka | 2.74, 5.84(at 25℃) |
| form | tablets |
| color | off-white to gray |
| PH | 4.0-4.1 (0.8g/l, H2O, 20℃) |
| PH Range | Non-B uorescence (3.1) to light green B uorescence (4.4) |
| Water Solubility | <0.1 g/100 mL at 21 ºC |
| Decomposition | 279-281 ºC |
| Merck | 14,5904 |
Mesalamine Usage And Synthesis
|
Uses |
Antibacterials for the treatment of tuberculosis. Mainly used to treat tuberculosis |
|
Description |
5-Aminosalicylic acid (5-ASA) is a metabolite and potential pharmacologically active component of sulphasalazine, a drug used in the treatment of Crohn's disease and ulcerative colitis. However, the mechanism by which this drug works has not been established. In whole blood assays, 5-ASA proves to be a weak, non-selective inhibitor of both COX-1 and COX-2 with IC50 values of 410 and 61 μM, respectively. In ionophore-stimulated colonic mucosal cells, 1 mM 5-ASA does not inhibit prostaglandin E2 (PGE2) production, but does reduce leukotriene B4 (LTB4) synthesis approx. 50%. In ionophore-stimulated human leukocytes, 400 μM 5-ASA reduces LTB4 production approximately 20%. 5-ASA does not inhibit 15-hydroxy PGDH at concentrations up to 50 μM. Fisalamine is an intestinal metabolite of sulfasalazine useful in the treatment of ulcerative colitis and to a lesser degree in the management of Crohn's disease. Administered as a suppository, it appears to lack the hypersensitivity-type side effects of sulfasalazine. |
|
Chemical Properties |
White to Off-White powder |
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