Basic information
|
Product Name: |
Tacrolimus |
|
Synonyms: |
16-dimethoxy-4,10,12,18-tetramethyl-8-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,[3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;L679934;Protopic;Fujimycin;Prozraf |
|
CAS: |
104987-11-3 |
|
MF: |
C44H69NO12 |
|
MW: |
804.02 |
Physical and chemical properties
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Melting point |
113-115°C |
|
Boiling point |
871.7 |
|
Density |
1.19 |
|
Flash Point |
481.0 ℃ |
|
Appearance |
White or grayish white crystalline powde |
Usage
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Uses |
A macrolide that binds to FK506 binding protein (FKBP) to form a complex, thereby reducing the activity of peptidylprolyl isomerase in T cells |
Tacrolimus, also known as FK506, is a kind of macrolide antibiotic isolated from Streptomyces. It is a powerful new immunosuppressant. It can inhibit the release of interleukin-2 (IL-2) and inhibit T lymphocyte completely. It is 100 times stronger than CSA. In recent years, as the first-line drug for liver and kidney transplantation, it has been listed in 14 countries such as Japan and the United States. Clinical experiments show that it has a good effect in heart, lung, intestine, bone marrow transplantation. At the same time, FK506 also plays an active role in the treatment of atopic dermatitis (AD), systemic lupus erythematosus (SLE), autoimmune ophthalmopathy and other autoimmune diseases.
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