Vildagliptin Basic information
| Product Name: | Vildagliptin |
| Synonyms: | Vildagliptin (NVP-LAF 237);(-)-(2S)-1-[[(3-Hydroxytricyclo[3.3.1.1[3,7]]dec-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile;2-Pyrrolidinecarbonitrile, 1-(((3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)amino)acetyl)-, (2S)-;Galvus;Laf 237;Unii-I6B4B2U96p;Vidagliptin (see vildagliptin);Vildagliptin |
| CAS: | 274901-16-5 |
| MF: | C17H25N3O2 |
| MW: | 303.4 |
| EINECS: | 630-410-0 |
Vildagliptin Chemical Properties
| Melting point | 153-155℃ |
| alpha | -78.3° (c = 9.73 in methanol) |
| Boiling point | 531.3±50.0 °C(Predicted) |
| density | 1.27 |
| Fp | 275.1℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 45 mg/ml), in DMF (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml). |
| pka | 15.05±0.40(Predicted) |
| form | solid |
| color | White |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months |
Vildagliptin Usage And Synthesis
| Chemical Properties | White Solid |
| Uses | Labelled Vildagliptin. It is a new oral anti-hyperglycemic agent of a new dipeptidyl peptidase-IV (DPP-IV) inhibitor class of drugs. Antidiabetic. |
Vildagliptin CAS NO.274901-16-5 is an effective and reversible specific competitive dipeptidyl peptidase 4 (DPP-4) inhibitor. Its IC50 is 2-3 nmol / L. Compared with other similar peptidases, the specific IC50 of DPP-4 inhibition reached 200 μ mol / L, which could avoid the immuno, histopathological and gastrointestinal toxicity of dpp-8 and dpp-9.
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