Basic Information
|
Product Name |
Trelagliptin |
|
Synonyms |
SYR-472;2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile; UNII-Q836OWG55H; (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile. |
|
CAS |
865759-25-7 |
|
MF |
C18H20FN5O2 |
|
MW |
357.38200 |
Chemical Properties
|
Melting Point |
No Information |
|
Storage Temp. |
Should not exceed 37 ° C |
|
Appearance And Properties |
White to beige solid |
|
Psa |
97.05000 |
|
Logp |
1.29888 |
|
Density |
1.57 |
|
Boiling Point |
No Information |
|
Refractive Index |
No Information |
|
Flash Point |
No Information |
Usage And Synthesis
|
Uses |
Troglitin intermediates |
|
Description |
No Information |
Mechanism of action
When we eat, the body secretes incretin, which is mainly composed of pancreatic islet glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP). These two hormones can promote the secretion of insulin by pancreatic β cells, thereby reducing blood sugar. There is also an enzyme in our body, called dipeptidyl peptidase-4 (DPP-4), which breaks down secretin, and troxagliptin is a DPP-4 inhibitor. It will inhibit the degradation of incretin by inhibiting DPP-4, so that incretin will work for a long time, stimulate pancreatic β cells to secrete insulin, and maintain the blood sugar of diabetic patients at a normal value.
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