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Name
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3-Methyl-6-nitroindazole
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|---|---|
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Synonyms
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3-Methyl-6-nitroindole; 3-Methyl-6-Nitro-1H-Indole;
3-METHYL-6-NITRO-1H-INDAZOLE;
3-METHYL-6-NIFRO-1H-INDAZOLE, 99+%;
3-Methyl-6-nitro-2H-indazole;
3-METHYL-6-NIFRO-1H-INDAZOLE, 97%;
3-Methyl-6-nitro-1H-indaz...
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CAS
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6494-19-5
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MF
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C8H7N3O2
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MW
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177.16
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EINECS
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613-731-0
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Melting Point
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187-188°C
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Boiling Point
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384.9±22.0 °C (Predicted)
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Density
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1.437
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Storage Conditions
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Sealed in dry, Room Temperature
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Solubility
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Slightly soluble in chloroform, methanol
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Form
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Solid
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pKa (Acidity Coefficient)
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11.47±0.40 (Predicted)
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Color
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Beige to dark yellow
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Usage
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Core intermediate in the pharmaceutical field: It is mainly used for synthesizing anti-tumor, anti-inflammatory and analgesic drugs, and can also serve as a research precursor for potential drugs such as neuroprotective, antibacterial/antiviral agents. Through chemical modification of groups like nitro and methyl in its molecule (e.g., reducing the nitro group to an amino group followed by further reactions), it can help construct the core structure of drug molecules. These molecules act on tumor cell targets (such as tyrosine kinases and PARP enzymes) or inflammation-related receptors (such as COX-2 enzymes), facilitating the development of drugs for treating solid tumors, relieving inflammatory pain, etc.
Precursor/building block for materials and chemical research: In materials chemistry, it can be used as a precursor for organic optoelectronic materials (e.g., active layer materials for organic solar cells, light-emitting layer materials for OLEDs) and metal coordination materials (e.g., catalytic materials, magnetic materials, or MOF materials). In chemical research, it serves as a general synthetic building block with an indazole structure for constructing complex heterocyclic compounds, and can also act as a standard reference for chromatographic analysis (e.g., HPLC, GC) to detect its residual amount in drug synthesis or verify separation and purification methods.
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