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Name
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3-Amino-1,2-propanediol
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|---|---|
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Synonyms
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3 - Aminopropane - 1,2 - diol 99%; 3 - AMINO - 1,2 - PROPANEDIOL 98%;
Aminopropylene glycol; 1 - Amino - 2,3 - dihydroxypropane; Isoserinol;
Glycerol α - monoamine; 3 - Amino - 1,2 - propanediol, 98%; 3 - Amino - 1,2 - propanediol (Isoserinol)
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CAS
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616-30-8
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MF
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C3H9NO2
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MW
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91.11
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EINECS
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210 - 475 - 8
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Melting Point
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55 - 57 °C
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Boiling Point
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264 - 265 °C at 739 mm Hg (lit.)
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Density
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1.175 g/mL at 25 °C (lit.)
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Vapor Pressure
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< 1 hPa at 20 °C
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Refractive Index
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n20/D 1.492 (lit.)
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Flash Point
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> 230 °F
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Storage Conditions
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Store below +30°C.
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Solubility
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Solubility in water > 1000 g/L
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Form
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Liquid (highly viscous)
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Acid Dissociation Constant (pKa)
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12.11 ± 0.35 (predicted)
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Color
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Transparent, colorless to pale yellow
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Specific Gravity
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1.175
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pH Value
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11 (100 g/L, H2O, 20°C)
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Water Solubility
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Soluble
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Sensitivity
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Hygroscopic
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Usage
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It is used in the preparation of antiviral drugs (such as some anti-influenza and anti-hepatitis virus drugs), antibacterial drugs, and drugs for treating cardiovascular diseases (such as drugs for regulating blood lipids and improving blood circulation). Its amino group can participate in reactions like amidation and cyclization, while its hydroxyl groups can introduce other functional groups, facilitating the construction of the core structure of drug molecules.
It is used to synthesize contrast agent intermediates: in the field of medical imaging, it can serve as a synthetic precursor for iodine-containing contrast agents (such as those used in CT scans). By modifying its hydroxyl and amino groups, the water solubility and biosafety of the contrast agent can be enhanced.
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