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Product Name:
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3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea |
| Synonyms: |
3-methyl-1-[(3S)-2-oxooxolan-3-yl]-3-{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}urea; (S)-1-[(2-Isopropyl-4-thiazolyl)methyl]-1-methyl-3-(2-oxo-3-tetrahydrofuranyl)urea; Urea,N-methyl-N-[[2-(1-methylethyl)-4-thiazolyl]meChemicalbookthyl]-N'-[(3S)-tetrahydro-2-oxo-3-furanyl]-; (L)-1-(2-Isopropyl-thiazol-4-yl-methyl)-1-methyl-3-(2-oxotetrahydrofuran-3-yl)-urea; (S)-1-((2-isopropylthiazol-4-yl)methyl)-1-methyl-3(2-oxotetrahydrofuran-3-yl)urea;RMA-358 |
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CAS:
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1004316-93-1 |
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MF:
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C13H19N3O3S |
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MW:
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297.37 |
| Form | liquid |
| Color | light brown to brown |
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Boiling point |
564.2±50.0 °C(Predicted) |
| Density | 1.27±0.1 g/cm3(Predicted) |
| pKa | 12.30±0.20(Predicted) |
| Flash point | >70℃ |
| Solubility | DMSO completely dissolved |
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Storage temp
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condition ≤25℃, moistureproof, avoid direct sunlight. |
Usage
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Uses
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Pharmaceutical Intermediate (1) Potential precursors for antibacterial/antifungal drugs The thiazole ring is the core structure of many antibiotics (such as cephalosporins and fluoroquinolones) and antifungal drugs. This compound may be used to synthesize: Novel antibacterial agents (such as oxazolidinone and tetrahydrofuran-fused thiazole derivatives for drug - resistant bacteria). Antifungal drugs (such as improved structures of fluconazole and echinocandin classes). (2) Central nervous system drugs (CNS Drugs) The tetrahydrofuran (THF) structure is commonly found in neurotransmitter modulators (such as 5 - HT receptor and GABA receptor ligands). This compound may be used to synthesize: Anxiolytic and antidepressant drugs (such as thiazole derivatives of 5 - HT reuptake inhibitors). Analgesic drugs (such as improved structures of opioid or non - opioid analgesics). (3) Anticancer agents The combination of thiazole and urea groups may endow the compound with kinase inhibitory activity (such as EGFR and VEGF inhibitors). This compound may serve as an intermediate for targeted anticancer drugs, used to synthesize tetrahydrofuran - containing thiazole - urea anticancer agents. Agrochemical Intermediate The thiazole ring is the key structure of many insecticides and fungicides (such as thiazole fungicides and pyrazole insecticides). This compound may be used to synthesize: Novel fungicides (such as thiazole fungicides containing tetrahydrofuran). Insecticides (such as thiazole - urea compounds acting on the insect nervous system). |
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