Description

(S)-3-Hydroxypyrrolidine ( CAS: 100243-39-8, (S)-3-PYRROLIDINOL(S)-3-HYDROXYPYRROLIDINE;(S)-(-)-3-PYRROLIDINOL;(S)-3-PYRROLIDINOL;(S)-3-Hydroxypyrrolidine((S)-3-Pyrrolidinol);(S)-3-HYDRChemicalbookOXYPYROLIDINEHYDROCHLORIDE;(S)-(-)-3-Hydroxypyrrolidine,99%,ee99+%;(S)-3-Pyrrolidinol,99%e.e.;(S)-3-Pyrrolidinol>=97.0%(sumofenantiomers,GC)) is an optically active cyclic amino alcohol with the chemical formula C₄H₉NO. Its structure contains both a secondary amine and a hydroxyl functional group, making it an important chiral building block in organic synthesis. This compound is widely used in medicinal chemistry and fine chemical synthesis for the design and preparation of bioactive molecules containing a pyrrolidine scaffold, commonly found in the research and development of central nervous system agents, antimicrobials, enzyme inhibitors, and other biologically active compounds. Its (S)-configuration plays a key role in asymmetric synthesis and chiral induction. In practical use, refer to the Safety Data Sheet (SDS) provided by the supplier, and pay attention to its stability and potential irritancy during storage and handling.

◆Chemical Properties

Melting Point	15°C
Optical Rotation	-6.5° (c=3.5% in MeOH)
Boiling Point	108–110°C (8 mmHg)
Density	1.078 g/mL at 20°C (lit.)
Refractive Index	n20/D 1.490
Flash Point	>110°C
Storage Conditions	2–8°C
Solubility	Slightly soluble in chloroform, slightly soluble in methanol
Acidity Coefficient (pKa)	14.91±0.20 (Predicted)
Physical State	Liquid after melting
Color	Transparent pale yellow to yellow
Specific Gravity	1.078
Optical Rotation	[α]20/D 6.5±1.5°, c = 3.5% in methanol

◆Applications

Sr. No.	Description	Application
1	Chiral building block for drug synthesis	Synthesis of CNS-active agents, enzyme inhibitors, and bioactive pyrrolidine-containing pharmaceuticals
2	Intermediate in asymmetric synthesis	Enabling stereoselective construction of chiral drug candidates
3	Pharmacophore in medicinal chemistry	Core scaffold for developing neuroprotective, antimicrobial, and receptor-targeting therapeutics
4	Protecting group precursor in peptide synthesis	Temporary protection of amines/hydroxyls during complex molecule assembly
5	Chiral auxiliary in catalytic reactions	Facilitating enantioselective transformations in API manufacturing

◆Product Specifications

(S)-3-Hydroxypyrrolidine (HMDS, CAS NO.100243-39-8) should be handled according to standard chemical industry and pharmaceutical intermediate safety procedures. Appropriate industrial hygiene and protective measures must be followed during handling, storage and operation.

Use appropriate personal protective equipment (PPE)
Avoid inhalation of vapor or mist and contact with skin, eyes and clothing
Handle in controlled, well-ventilated environments
Keep away from heat, sparks, open flames and hot surfaces
Protect from moisture and avoid contact with water
Follow chemical handling, storage and containment protocols
Refer to Safety Data Sheet (SDS) for detailed safety, handling and storage information

Hot Tags: cas no100243-39-8 (s)-3-hydroxypyrrolidine, China, manufacturers, suppliers, factory, custom, wholesale, CAS NO 540 88 5, CAS NO 25561 30 2, CAS NO 100 52 7, Ethyl trifluoroacetate, CAS NO 112 55 0, Phthalide