Basic information
|
Product Name: |
11-alpha-Hydroxycarvenone |
|
Synonyms: |
(11a,17a)-11,17-Dihydroxy-3-Oxo-Pregna-4,6-Diene-21-Carboxylic Acid;3-(3-oxo-11a,17ss-Dihydroxy-4,6-Diene-Pregna-17a-yl)Propanoic Acid Lactone |
|
CAS: |
192569-17-8 |
|
MF: |
C22H28O4 |
|
MW: |
356.46 |
|
EINECS: |
606-276-4 |
Physical and chemical properties
|
Melting point |
232-234°C |
|
Density |
1.25 |
|
Storage temp. |
-20°C Freezer |
| Appearance | Yellow crystalline solid |
Usage
|
Description |
Antihypertensive drugs, pharmaceutical raw materials or intermediates of eplerenone. |
A series of useful canrenone derivatives can be obtained from 11α-hydroxylated canrenone. Based on the use of microbial transformation to obtain 11α-hydroxylated canrenone, GDSearle in the United States has obtained a new selective steroidal aldosterone receptor antagonist epleren after six (or seven) chemical synthesis. Ketones were approved by the FDA in April 2002, and were listed in the United States by Pharmacia in 2003. Clinical studies have found that compared with Canrenone and Spironolactone in the treatment of cardiovascular diseases such as hypertension, Eplerenone has significantly reduced side effects and significantly reduced the mortality of heart failure.
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