Cytosine Basic information
|
Product Name: |
Cytosine |
|
Synonyms: |
4-AMINO-2(1H)-PYRIMIDINONE;4-AMINO-2(1)-PYRIMIDONE;4-AMINO-2-PYRIMIDINOL;4-AMINO-2-OXO-1,2-DIHYDROPYRIMIDINE;4-AMINO-2-HYDROXYPYRIMIDINE;2-Oxy-4-amino pyrimidine;AURORA KA-682;CYTOSINE |
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CAS: |
71-30-7 |
|
MF: |
C4H5N3O |
|
MW: |
111.1 |
|
EINECS: |
200-749-5 |
Cytosine Chemical Properties
|
Melting point |
>300 °C(lit.) |
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Boiling point |
208.2°C (rough estimate) |
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density |
0,48 g/cm3 |
|
refractive index |
1.5000 (estimate) |
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storage temp. |
2-8°C |
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solubility |
Clear to very slightly hazy colorless to faint yellow solution at 50 mg/ml in 0.5 M HCL. |
|
form |
Crystalline Powder |
|
pka |
4.60, 12.16(at 25℃) |
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color |
White to slightly yellow |
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Water Solubility |
soluble |
|
Merck |
14,2795 |
|
BRN |
2637 |
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Stability: |
Stable. Incompatible with strong oxidizing agents. |
Cytosine Usage And Synthesis
| Description | Cytosine is pyrimidine; along with adenine and guanine they account for the fi ve nucleic acid bases. Pyrimidines are heterocyclic single-ringed compounds based on the structure of pyrimidine. Cytosinelike adenine and guanine, form nucleosides and nucleotides in RNA and DNA. When the bases combine with ribose, a ribonucleoside forms; and when it attaches to deoxyribose, a deoxyribosenucleoside is formed. Names of the nucleoside are summarized in Table 29.1.these in turn combine with phosphoryl groups, in a process called phosphorylation, to form their respective nucleotides that form nucleic acids.the nucleotides can be tri, di, and mono phosphate nucleotides similar to the way in which adenine forms ATP, ADP, and AMP. |
|
Chemical Properties |
White Solid |
|
Uses |
Widely distributed in nature; constituent of nucleic acids |
Cytosine Specification
|
Description |
White or almost white |
|
Identification |
The RT of the major peak complies with the RS |
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Loss on drying |
≤0.5% |
|
Residue on ignition |
≤0.1% |
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Uracil |
≤0.15% |
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Any other individual impurity(biggest) |
≤0.15% |
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Total impurity |
≤0.5% |
|
Assay(HPLC) |
98-102%(ON the dried basis) |
Cytosine, a white crystalline powder, slightly soluble in water and ethanol, insoluble in ether, 300℃, 100℃, brown at 300℃, 320℃; CAS NO.71-30-7, chemical name: 4-amino-2-hydroxypyrimidine, is an important active raw material involved in DNA, RNA synthesis in organisms, is one of the pyrimidine bases forming nucleic acid. Cytosine is an important intermediate in fine chemicals, pesticides and medicine. On pesticides, the first discovered cytosine nucleotide peptide type of the new antibiotic, it is a high efficiency, low toxicity, low residue of the broad-spectrum agricultural antibiotic. In the field of medicine, cytosine is a nucleic acid substance, which can be used as an antiviral drug, mainly used in the synthesis of anti-AIDS drugs and anti-hepatitis B drug lamivudine, anti-cancer drug gemcitabine, and 5-fluoropytosine.
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