Tenofovir disoproxil Basic Information
| Product Name | Tenofovir disoproxil |
| Synonyms | (R)-(((((1-(6-AMino-9H-purin-9-yl)propan-2-yl)oxy)Methyl)phosphoryl)bis(oxy))bis(Methylene) diisopropyl dicarbonate;(R)-(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)-bis(oxy))bis(methylene) diis;2,4,6,8-Tetraoxa-5-phosphanonanedioicacid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-,1,9-bis(1-Methylethyl) ester, 5-oxide;TenofivirDisoproxilFumarate;SRY;Testis-determining factor;Tenofovir disoproxil, >=98%;Tenofovir disoproxil aspartate |
| CAS | 201341-05-1 |
| MF | C19H30N5O10P |
| MW | 519.44 |
| EINECS | 606-442-6 |
Tenofovir disoproxil Chemical Properties
| Boiling point | 642.7±65.0 °C(Predicted) |
| Flash Point | 342.5ºC |
| density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| Psa | 195.25000 |
| Logp | 3.61680 |
|
Refractive Index |
1.578 |
| solubility | DMSO: ≥ 38 mg/mL (73.16 mM) |
| pka | 4.20±0.10(Predicted) |
| Vapor Pressire | 2.06E-16mmHg at 25°C |
Tenofovir disoproxil Usage And Synthesis
|
Uses |
Tenofovir Disoproxil is a therapeutic option for nucleos(t)ide analog (NA)-experienced chronic hepatitis B (CHB) patients infected with hepatitis B virus (HBV). Also, it is an intermediate used in the synthesis of Tenofovir Disoproxil Dimer (T018515), which is a Tenofovir Disoproxil impurity. |
|
Description |
Tenofovir disoproxil belongs to a class of medications called antiretroviral known as a nucleotide reverse transcriptase inhibitor, which is commonly used to treat the infection caused by the human immunodeficiency virus (HIV) generally in combination with other antiviral agents. It can also be used for prevention of HIV/AIDS among those people who are at high risk before exposure, such as injection through sexual transmission or injection of drugs. It functions by blocking reverse transcriptase, an enzyme vital to viral duplication in people infected HIV. Besides, it is effective to treat chronic hepatitis B, in which it helps prevent the enzymes needed for the hepatitis B virus to reproduce from working properly. However, tenofovir disoproxil does not cure HIV/AIDS or hepatitis B. It helps lower the amount of HIV or hepatitis B virus in the body and slow down the progression of the disease. Tenofovir was patented in 1996 and approved for use in the United States in 2001. |
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