Tenofovir Disoproxil Fumarate Basic Information
| Product Name | Tenofovir Disoproxil Fumarate |
| Synonyms | 2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-, bis(2,2-dimethylpropyl) ester, 5-oxide, (R)-;Aids031697;Aids-031697;Bis(neopentyloc)pmpa;Tenofovir diisoproxil fuMarate;Tenofovir dipivoxil FuMarate(TDF);Tenofovir Disoproxil Fumarate (200 mg);2,4,6,8-Tetraoxa-5-phosphanonanedioic acid, 5-[[(1R)-2-(6-aMino-9H-purin-9-yl)-1-Methylethoxy]Methyl]-, 1,9-bis(1-Methylethyl) ester, 5-oxide, (2E)-2-butenedioate |
| CAS | 202138-50-9 |
| MF | C23H34N5O14P |
| MW | 635.515 |
| EINECS | 687-766-5 |
Tenofovir Disoproxil Fumarate Chemical properties
| Melting Point | 113-115°C |
| Storage Temp. | 2-8°C |
| Appearance | White to beige powder |
| Density | 1.45 g/cm3 |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| Boiling Point | 642.7ºC at 760 mmHg |
| Flash Point | 342.5ºC |
Tenofovir Disoproxil Fumarate Usage And Synthesis
| Description | Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir . Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase. Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes. |
| Chemical Properties | White Solid |
| Uses |
An acyclic phosphonate nucleotide analog and selective HIV-1 RT inhibitor. Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral. |
It is used for adult patients with CHB who have evidence of virus replication and continuous elevation of serum aminotransferase (ALT or AST) or evidence of liver active disease. Including HBeAg-positive or HBeAg-negative adult patients with compensated CHB. It is also used as a nucleotide reverse transcriptase inhibitor and is a prodrug of Tenofovir (PMPA, 2). It is mainly used clinically to treat human immunodeficiency virus infection.
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