Omeprazole Basic information
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Product Name: |
Omeprazole |
|
Synonyms: |
1h-benzimidazole,5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulf;2-Chloromethyl-3,5-dinmethyl-4-methoxypyridine;5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazol;audazol;aulcer;belmazol;ceprandal;elgam |
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CAS: |
73590-58-6 |
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MF: |
C17H19N3O3S |
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MW: |
345.42 |
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EINECS: |
615-996-8 |
Omeprazole Physical and Chemical Properties
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Melting point |
156 °C |
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Boiling point |
600.0±60.0 °C(Predicted) |
| density | 1.332 g/cm3 |
| Fp | 9℃ |
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Storage Condition |
2-8℃ |
| solubility | H2O: 0.5 mg/mL |
| pka | pKa 4.14/8.9(H2O,t =25,I=0.025) (Uncertain) |
|
Form |
solid |
| color | white |
| Merck | 14,6845 |
| Stability | Stable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark. |
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Water Solubility |
Soluble in water (0.5 mg/ml), DMSO (25 mg/ml), and ethanol (4.5 mg/ml) |
Omeprazole Usage
| Description | Omeprazole is a potent gastric antisecretory agent with selective inhibitory effect on the H+,K+-ATPase proton pump. It is highly effective in the treatment of duodenal ulcer and Zollinger-Ellison syndrome, and is reportedly superior to ranitidine in the management of reflux esophagitis. |
| Chemical Properties | White Crystalline Solid |
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Uses |
Omeprazole is a proton pump inhibitor used to treat diseases like gastroesophageal reflux disease (GERD), used for gastric and duodenal ulcers, reflux or erosive esophagitis, and Zollinger-Ellison syndrome. It is also effective for gastric and duodenal ulcers that are ineffective with H2 receptor antagonists. Injections of Omeprazole can also be used for: 1 gastrointestinal bleeding, such as peptic and anastomic ulcer bleeding, and the prevention of severe diseases (such as cerebral hemorrhage, severe trauma, etc.) and gastric surgery caused by upper intestinal bleeding; 2 acute gastric mucosal damage complicated by stress or nonsteroidal anti-inflammatory drugs; 3 general anesthesia, post-surgery, or coma patients, to prevent acid reflux and aspiration pneumonia; 4 Combined with amoxicillin and clarithromycin, or with metronidazole and clarithromycin, it can effectively kill Helicobacter pylori (Hp). |
Pharmacological action：Omeprazole is a proton pump inhibitor used to treat diseases such as peptic ulcer and gastroesophageal reflux disease (GERD). It can specifically act on the site of the proton pump of gastric parietal cells and transform it into sub The active form of sulfonamide is then irreversibly combined with the sulfhydryl group of the proton pump through the disulfide bond to form a complex of sulfinamide and proton pump (H+-K+-ATPase), thereby inhibiting the enzyme activity and making the parietal cell H+ cannot be transported into the gastric cavity, blocking the last step of Chemicalbook to stop gastric acid secretion, and greatly reducing the amount of gastric acid in the gastric juice. Therefore, this product has a strong and long-lasting inhibitory effect on gastric acid secretion caused by many reasons (such as basic gastric acid secretion and gastric acid secretion caused by histamine, pentagastrin and stimulation of the vagus nerve, including the inability of H2 receptor blockers. Inhibited gastric acid secretion caused by dibutyl cyclic adenylate). This is related to the irreversibility of the inhibitory effect of this product on the proton pump. The acid secretion can only be restored after a new proton pump is formed.
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