Tiopronin Basic information
|
Product Name: |
Tiopronin |
|
Synonyms: |
A-MERCAPTOPROPIONYL GLYCINE;ALPHA-MERCAPTO PROPIONYL GLYCINE;LABOTEST-BB LT00451995;TIOPRONIN;N-(2-MERCAPTOPROPIONYL)GLYCINE;TOPRONIN;(2-Mercaptopropionamido)acetic acid;(2-Mercaptopropionyl)glycine |
|
CAS: |
1953-02-2 |
|
MF: |
C5H9NO3S |
|
MW: |
163.19 |
|
EINECS: |
217-778-4 |
Tiopronin Physical and Chemical Properties
|
Melting point |
93-98 °C |
|
Boiling point |
418.3±30.0 °C(Predicted) |
| Density | 1.249(estimate) |
| Refractive index | 1.5216(estimate) |
|
Storage Condition |
Inert atmosphere,2-8°C |
| Pka | 3.36±0.10(Predicted) |
|
Form |
Solid |
| Color | White |
|
Solubility |
DMSO (Slightly), Methanol (Slightly) |
Tiopronin Usage
| Description | Tiopronin is a sulfiydryl derivative of N-propylglycine useful in the treatment of cystine urolithiasis in children. It is also reportedly effective in the management of rheumatoid polyarthritis, possibly due to its inhibitory effect on the free oxygen radicals produced by inflammatory macrophages and granulocytes. |
| Chemical properties | White Solid |
|
Uses |
It is used as antidote against heavy metal poisoning; hepatoprotectant; mucolytic. N-(2-Mercaptopropionyl)glycine or Tiopronin has been used:
|
clinical application
Tiopronin is mainly used in: ① fatty liver, early cirrhosis, acute and chronic hepatitis, alcohol and drug caused by the treatment of hepatitis. ② Treatment of heavy metal poisoning. ③ Reduce the side effects of chemotherapy and radiotherapy, increase white blood cells, and can prevent the occurrence of secondary tumors caused by chemotherapy and radiotherapy.
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