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Name
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N-(4,5-dimethylisoxazol-3-yl)-N-(methoxymethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide
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Synonyms
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N-(4,5-dimethylisoxazol-3-yl)-N-(methoxymethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide;
Benzenesulfonamide, N-(4,5-dimethyl-3-isoxazolyl)-N-(methoxymethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; N-[Methoxymethyl]-N-(4,5-dimethyl-3-isoxazolyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide;
N-(4,5-Dimethyl-3-isoxazolyl)-N-(methoxymethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide;
2-(N-(4,5-dimethyl-isoxazol-3-yl)-N-methoxymethyl-benzenesulfonamide)-boronic acid pinacol ester;
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CAS
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415697-56-2
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MF
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C19H27BN2O6S
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MW
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422.3
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Usage
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Suzuki coupling precursor in drug R&D: As a pharmaceutical intermediate with a boronic acid pinacol ester structure, it features high stability of the pinacol boronate group. It can efficiently introduce functional groups such as aromatic rings through Suzuki coupling reactions, facilitating the synthesis of tumor-related kinase inhibitors (e.g., EGFR, ALK inhibitors) and providing key structural units for the development of precision anticancer drugs.
Selective reaction intermediate in organic synthesis: The isoxazole ring, sulfamoyl group, and pinacol boronate group in the structure form multi-functional reaction sites, combining stability and reactivity. It is applicable to the directed synthesis of fine chemicals and novel drug molecules, especially in organic synthesis scenarios requiring precise construction of complex skeletons.
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