It is reported that the Lancet will publish a standing report of the Lancet Commission on Dementia in 2020. The report will cover relevant evidence that most dementias are preventable. For dementia patients, the goal should be to get the best possible care, which can only be achieved by discussing communication, eliminating misunderstandings, early diagnosis, and prioritizing the needs of patients and families.
About 20 million people worldwide suffer from dementia (Alzheimer’s disease is a type of Dementia) in 2018. By 2050, this number will increase to 152 million, which is three times that of the present. It is estimated that the cost of global social dementia in 2018 is $1 trillion, and by 2030 this number will increase to $2 trillion. (The term dementia is still used globally. In fact, dementia in Taiwan may be better)
According to a US survey, taking care of patients takes a long time and lasts. More than 60% of family members and nursing staff are affected by extreme emotional changes and mental stress, and one third of them have depression. All caregivers who care for Alzheimer's disease have a negative impact on their own health, work, income and family finances.
According to the 2015 economic cost survey for patients with dementia, the total annual treatment cost of Chinese dementia patients was $167.74 billion, and the annual treatment cost per patient was $19,144. The total annual treatment cost of dementia accounts for 1.47% of gross domestic product (GDP). (Alzheimer’s disease and other dementias)
Since 1998, at least 250 drugs have been dedicated to the development of diseases related to Alzheimer’s disease. However, there are currently only 4 new molecular entities (NCE) approved in the world: cholinesterase (AchE) inhibitor donepezil, rivastigmine, galantamine and NMDA antagonist memantine.
Globally, in addition to AchE inhibitors and NMDA antagonists, more companies are accumulating in β-amyloid receptor antagonists, β-secretase inhibitors, and 5-HT6 receptor antagonists. Target area such as tau protein.
