The Azvudine treatment team for the treatment of new coronavirus is chaired by Genuine Biotech. The Chinese Academy of Medical Sciences is responsible for pharmacology, efficacy, and pharmacokinetic research. Among them, Academician Wang Chen, President of the Chinese Academy of Medical Sciences, is responsible for clinical research, Beijing Ditan Hospital, Wuhan Zhongnan Hospital, etc. 10 Several hospitals are involved.
1. First, azvudine works well.
In February 2020, Azvudine was found to be able to resist the new coronavirus, and it was approved for Phase III clinical trials in April 2020. Now that Phase III clinical trials are over, some of the results we have seen are relatively optimistic.
The clinical effect of azvudine is as follows. Generally, the nucleic acid turns negative after 3-4 days of oral administration. About 300 to 400 cases were done in the second phase of clinical trials, and more than 800 cases were done in the third phase of clinical trials. From the results of Phase II clinical and some Phase III clinical trials, we can see that the nucleic acid turns negative in about 3-4 days. The medication can be stopped after 6-7 days, and usually discharged within 9 days.
And it doesn't matter whether the patient has taken any medicine before, or has been taking medicine for a while, he can still use azvudine. Azvudine is not like some drugs that need to be taken early in the infection of new coronary pneumonia, it does not need it. Therefore, the results of severe and mild medication are very similar.
2. Second, Azvudine treats both the symptoms and the symptoms.
At the cellular level, Azvudine’s antiviral strength is actually not as strong as Remdesivir, four or five times worse than Remdesivir, but the clinical effect is much better than Remdesivir, and it can be taken orally at 5mg, Remdesivir injection is 100mg.
This brings us to the question that there must be a factor at play that we don't understand. This question is the starting point for us to start this project. Azvudine was later found to be an RNA polymerase inhibitor. However, the general RNA polymerase inhibitor is a nucleoside drug, which requires three phosphorylation, and the phosphorylation process is actually relatively difficult. For example, Remdesivir adds phosphoric acid to it, but Azvudine does not add phosphoric acid. Later, we found that azvudine can be distributed to various organs in the body and complete three phosphorylation in the thymus.
The thymus gland is very important. At the age of 15, the thymus is the largest, and after the age of 45, the thymus shrinks to the size of childhood. So after the age of 45, the immunity of the average adult begins to decline, so it will get sick, such as tumors. The new crown is also more prone to death in older people because it has fewer T cells.
The answer we found is: Azvudine completes three phosphorylations in the thymus, clears the virus in the thymus, protects the immune system, and the immune system also has an antiviral effect.
So, I think this medicine is a dual treatment. The first is anti-virus, and its anti-virus is mainly concentrated in the thymus. The thymus is actually an amplifier that can destroy viruses throughout the body as long as the T cells are able to produce sufficient functions. The second item is to inhibit the function of the new coronavirus RdRP.
(Other data we have seen shows that after azvudine enters the human body, the distribution is relatively special, and the distribution on the thymus is the largest. Azvudine enters the body and does not stay in the blood for a long time. More It will be decomposed into the form of triphosphate and enter into the cell, which will remain in the CD4/CD8 cells, and the half-life in the cell is about 160 hours+)
Azvudine has the function of treating symptoms and root causes. Antiviral is the "symptoms", and thymus protection is equivalent to "root cause".
Source: eastmoney.com
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