With the mass epidemic of novel coronavirus, new virus mutant strains continue to appear, Alpha, Beta, Gamma, Delta, Omicron, etc. Some of these mutant strains have stronger infection ability or stronger immune escape ability, and the most concerned world is the Omicron mutant strains.
Recently, several variants of novel coronavirus Omicjunon have emerged, including BQ.1、BQ.1.1、BA.4.6、BF.7 And BA. New variants such as 2.75.2 attract the attention of WHO, which may have greater immune escape ability.
Professor Liu Shanxue, a Chinese virologist at Ohio State University, published a paper in the journal "Cell Host & Microbes" titled "" Enhanced Neutralization Resistance of SARS-CoV-2 Omicron Subvariants BQ ".1，BQ.1.1，BA.4.6，BF.7 and BA. Research paper of 2.75.2 ".
This study showed that, compared with the early strain BA.1 And BA.4 / 5 In contrast, all of these novel variants have enhanced immune evasion capacity, especially the B Q driven by the N460K and K444T mutations.1 And BQ.1.1 Variants, and the B A, driven by the F486S mutation.2.75.2 Variants, with greater immune evasion ability, and are better at avoiding the neutralizing antibodies produced by vaccines and infections.
In that study, the researchers analyzed the BQ.1、BQ.1.1、BA.4.6、BF.7 And BA.2.75.2 Variants, given in 3 doses of vaccine, BA.1 Patients, BA. Escape ability in antibodies produced in 4 / 5 patients.
According to the US CDC data, the BA.2.75.2 The variant is the Omicron BA. The mutant of 2, which is the most potent in evading the neutralizing antibody of all the variants tested, and currently, it represents only a small proportion of the reported disease in the United States, BQ.1 And BQ.1.1 Variants are becoming the predominant strain.
The results showed that three doses of the vaccine neutralized B Q compared with neutralizing antibodies against the original strain.1 And BQ. The antibody to 1.1 was reduced by about 20 times.
besides,BA.1 Neutralizing antibodies to the patient product, the neutralizing titers to the BQ series variant were significantly lower than those for the original strain, whereas BA. For 4 / 5 of the patients, the antibody titer to the BQ variant did not reach the detection level.
BQ.1、BQ.1.1 and BA2.75.2 showed strong anti-neutralization
The results showed that the antibodies produced by the early viruses did not effectively prevent the infection of the currently popular Omicron variants.
The researchers have also created structural models of individual amino acids altered by the latest mutations on the spike protein, identifying some key molecules for the reorganization of the new variants.
This model suggests that the N460K mutation can enable BQ.1 And BQ.1.1 More efficient entry into the host cells, and enhances the ability of the virus to bind to the host cells, which contributes to the disease onset, progression to more severe symptoms, and the disease transmission capacity.but BA. The neutralization resistance of 2.75.2 is mainly determined by the F486S mutation, which provides a valuable scientific basis for our understanding of the immune escape ability of these variants and our countermeasures.
According to the Beijing Daily, Li Dong, chief physician of the department of respiratory and infectious diseases at Beijing You'an Hospital, has said that the main strain in Beijing is the Olympic Secret army mutant BF.7. As one of the Omicjunon muants, BF.7 is highly infectious, with a viral transmission index of 5 – 6 and the Omicjon variant exceeding 10.
In addition, the Okeron mutant has stronger immune escape ability and reproduction in the upper respiratory tract, which means that the infected person can talk, cough, infect more cases, people around are more likely to infect, Ojon has more mild disease, and easy to reduce vigilance.
take part in BA.1、BA.2 And BA.5 Compared with the variants, the BF.7 has faster transmission speed and stronger transmission ability, which is the strongest transmission strain among the Omicjunon muants transmitted in China.
