Dendritic cells (dendritic cells) play a key role in processing and presenting antigens to primitive T cells to stimulate adaptive immunity. The circadian rhythm is known to help regulate multiple aspects of the body's immunity, but their role in their function is not clear.recently, Published in a study entitled "The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing" in the international journal Nature Communications, Scientists from the Royal College of Surgeons in Ireland and other institutions have revealed the molecular mechanisms behind the 24-hour body clock affecting the body's immune response to the vaccine.
The researchers analyzed alterations in mitochondria in key immune cells involved in the body's vaccine response, which may help to design and improve the timing of future vaccines to maximize their effectiveness. Previous results showed that humans respond more to certain vaccines, which may depend on the timing of the day, but the researchers suggest that the circadian clock can change the shape of mitochondria in dendritic cells, and changes in the structure of mitochondrial cells can affect the functioning of DCs throughout the day.
Researchers Annie Curtis professor said, our research found that explained the body response to the vaccine is a key aspect, and emphasizes the importance of the circadian clock in the body immunity function play, so the researchers can apply this understanding in the process of vaccine development, to ensure that we can get the biggest benefit from vaccination. The circadian clock in dendritic cells controls whether the mitochondria will form one of two shapes, That is, long strings of network structures or dotted fragments of crushing effect; It is during the formation of this network-like shape that, Vaccination is the most effective, Because dendritic cells have a good ability to break down the vaccine into small blocks to interact with the host body's immune cells (T cells), In this study, Researchers have utilized a method to induce the reticulation phase of mitochondria, And thus important for vaccine design, This may then help to optimize the body's immune response, Instead of considering the time of vaccination in the day.
In recent years, mitochondria, the importance of mitochondria has gone beyond their common label as a "cellular energy factory," especially within the immune system cells, and the researchers are pleased to reveal a new link to the body's immune system and vaccine response. In conclusion, the results suggest that the rhythmic change of mitochondrial calcium plasm associated with altered mitochondrial morphology in dendritic cells may help to modulate the process of processing of antigen presentation in the host organism.
