Trial Registration :Chinese Clinical Trial Registry: ChiCTR 2400092219 Keywords Chromatometry; Drug effects; Hair; Mass spectrometry; Melanin; Therapeutics;Tranexamic acid
Methods and Results:
Seven middle-aged East Asian women completed a 3-month prospective observational study, taking 500 mg of oral TXA daily, with interruptions during menstruation.
Hair samples were collected from 10 scalp regions before and after treatment. Melanin content was measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and hair color changes were assessed with a chromometer.
One participant was excluded for dyeing their hair during the study. After 3 months of TXA treatment, no statistically significant changes in hair melanin content or color were observed, even when accounting for individual variations.
Discussion:
The findings indicate that daily oral administration of 500 mg TXA for 3 months does not significantly affect hair melanin levels or color in middle-aged East Asian women.
This provides reassurance for patients and clinicians concerned about hair pigmentation during TXA therapy.
The results suggest TXA exerts a selective effect on UV-induced skin pigmentation without interfering with melanin production in hair follicles. Future research is recommended to explore TXA's effects across diverse populations.
