According to the American Chemical and Engineering News (C&EN), the American Chemical Abstracts Service (CAS) registered the 150 millionth unique chemical substance-2-aminopyrimidine carbonitrile derivative.
CAS said that such a milestone is very important. It is not only a number, it is of great significance to the research direction. With the rapid development of global chemical research, CAS took about 40 years to register 25 million substances in 2005. In the past four years, 50 million substances have been registered.
The 150 millionth chemical substance patent belongs to Merck. It is one of several promising compounds studied as TBK and IKKε inhibitors in the treatment of cancer and immune diseases (including rheumatoid arthritis, systemic lupus erythematosus, and lupus nephritis). One.
The CAS registration number granted to this substance is 2306877-20-1. Its full name is 2-[[3,3-Difluoro-1-[(2R)-2-hydroxy-1-propoxy]-4-piperidinyl]oxy]-5-[2-[[5 -[(2R)-2,4-Dimethyl-1-piperazinyl]-6-methoxy-2-pyridyl]amino]-4-pyrimidinyl]benzonitrile.
The CAS Registry database was established in 1965 and is dedicated to identifying and collecting information on chemical substances. It is the world's largest database of unique chemical substances that has been manually indexed.
