At present, the official website of the World Health Organization has registered 110 new coronary pneumonia vaccines under development, of which 8 have entered clinical trials. Four vaccines in China have entered clinical trials. Emergency use in September. But at the same time that vaccine research and development is advancing by leaps and bounds, people are beginning to worry about the protection capabilities of vaccine bottles.
Will the vaccine get stuck in the neck because of the bottle?
Unexpectedly, in the global epidemic, notched hoods, lack of medicines, lack of ventilator, this time even glass bottles are missing?
It is not clear how many vaccine bottles are stored in the world. Now, the most clear statement is that on April 30th, Oxford University Professor of Medicine John Bell said on the British media BBC program, "There are only 200 million vaccine bottles in the world. Used".
But at present, countries still need glass vials to ensure the continuous supply of other key vaccines (such as meningitis, flu and typhoid).
At the end of April, Gates, who was busy fighting the epidemic in the United States, said: "Even there are not enough reserves in the world for vaccine bottles and filling procedures."
The world's four major vaccine manufacturers-GlaxoSmithKline, Merck, Sanofi, and Pfizer have produced nearly 90% of the world's vaccines.
When asked about small glass bottles, GlaxoSmithKline responded more "decently": "Considering current and future needs, we will continue to work closely with suppliers, including glass bottle suppliers."
Vijay Chamant, the former head of vaccine manufacturing at Merck Group, said directly, "The production task is difficult to solve. I can't sleep at night thinking about this matter."
And according to the current research progress, people may need to be vaccinated with the new coronavirus more than once to enhance their immunity to the new coronavirus.
In other words, perhaps one person needs many vaccine bottles. There are currently 7.59 billion people in the world. How many glass bottles are needed? Pacific Securities' pharmaceutical research team calculated an account for us:
Source: Pacific Securities
In the end, several doses of the vaccine have the best immunization effect, and it is not known how much the vaccine can penetrate. With a penetration rate of 40%, two injections would require 6 billion glass vials. If there are only 200 million in the world that are still used for other vaccines, the gap is indeed a bit large.
Therefore, the former director of the US Advanced Research and Development Agency for Biomedicine, who was dismissed recently, once declared on May 5 that he had warned the US Department of Health that the glass vials used for vaccines were "seriously in short supply." US vaccine demand may take up to two years. "
It seems that the supply and guarantee of glass vials will really face many challenges.
Main material of vaccine bottle:
Glass products, rubber stoppers, and sealing rings are the main materials of vaccine bottles.
In view of the shortage of the new crown vaccine, the vaccine may not exist in a single storage form. It is likely that the vial, ampoule and other forms will appear, which is a test for glass materials of different materials. The common vaccine bottle is medium borosilicate glass, which has good thermal shock resistance and water resistance, and is mostly used for packaging of various injections, blood, vaccines and other drugs.
The main material of the rubber plug and sealing ring is rubber, and medical and health rubber products are generally made of rubber NR, IIR, PU and silicone rubber.
Domestic vaccine-related packages are ready
On May 17, the China Vaccine Industry Association, based on the observation and industry data of the vaccine bottle industry, said after communicating with several benchmarking companies that China has an industrial foundation for the production of high-quality vaccine bottles. According to incomplete statistics, the annual output can reach at least 80 More than 100 million, can meet the demand for new crown vaccine production. According to the global new crown vaccine R & D progress, vaccine bottle manufacturers currently have sufficient preparation time and capacity basis. As long as the new crown vaccine is successfully developed and the form and specifications of packaging products are determined, vaccine bottle manufacturers can quickly release capacity and continue to orderly to satisfy the market's needs.
Not only the production capacity of vaccine bottles is ready, but even the qualified new crown vaccine production workshop has been built.
Recently, the first domestic P3 biopharmaceutical production workshop project undertaken by China Electronics System Engineering Fourth Construction Co., Ltd. (hereinafter referred to as "China Electric Fourth Company"), a subsidiary of China Electronics, was successfully delivered.
This is currently the world's largest new crown vaccine production workshop, with an annual production capacity of 100 million doses after mass production, with production conditions to meet large-scale emergency use and routine vaccination. Especially in the absence of domestic standards for the construction of high-level biosafety production workshops for human vaccines, the completion of this project fills the biosecurity gap in the field of vaccines for the prevention and control of major domestic epidemics. And vaccine development is of great significance.
Source: Mobei Public Account
