Uracil is a unique base of ribonucleic acid, also called RNA. It corresponds to ribonucleotide, also called thymine in DNA. The main function is that in the process of DNA transcription, the DNA cell nucleus is processed by helicase and paired with free base pairs to form single-stranded RNA to become messenger RNA, which exerts the genetic function of nucleotides. There is a pairing principle in this process. , Uracil is a base that can be paired. Uracil is an important part of RNA.
Development status of uracil industry
Uracil is used in organic synthesis and biochemical research, as well as in the synthesis of uridine and other pharmaceutical intermediates, animal feed additives, ink stabilizing additives, etc. The uracil production process is an innovative one-step production method optimization project product, which replaces the expensive palladium-carbon production process and the thiourea production process, which greatly reduces production costs and pollution during the manufacturing process.
Most of the bulk chemical raw material market in China's current uracil industry has become saturated. When the development of basic chemical production is hindered, it has become an inevitable choice for the development of enterprises to shift to the high-value-added fine chemicals and specialty chemicals. Strengthening technological innovation, adjusting and optimizing the structure of fine products, focusing on the development of high-performance, specialization, and green products will have an impact on the cyclical changes of the industry and is also the direction of the development of the uracil industry.
In terms of drugs, on the one hand, it can be used as a drug such as uracil tegafur tablets. The indication is that the clinical application is the same as that of fluorouracil. It is mainly used for digestive system cancer, breast cancer and thyroid cancer. It can also be used with schitomycin Combined application to treat advanced gastric cancer, the effective rate can reach 54.3% to 56.9%. It has become a key program widely used in Japan and my country. The combined application of this product with adriamycin and pingyangmycin also has a good effect in the treatment of esophageal cancer; on the other hand, it can be used as a synthetic antitumor drug 5-fluorouracil and its derivatives such as It is an important intermediate for adding fluoride, difurfururacil, deoxyfluridine, carmofluoride and antiviral 5-iodo-2'-deoxyuridine.
Source: Chemicalbook
