Another year of Tobacco Free Day has arrived, and this year is the 33rd World No Tobacco Day initiated by the World Health Organization. Tobacco harm is one of the most serious public health problems in the world, and smoking and second-hand smoke problems seriously endanger human health.
According to incomplete statistics, the number of smokers in my country has exceeded 300 million, ranking first in the world. Quitting smoking is an urgent task. Many people are also trying to quit smoking. The success rate is often not high.
Why was smoking cessation unsuccessful?
(1) Physiological dependence. Nicotine is one of the main components of cigarettes. It takes only 8 seconds for nicotine to reach the brain after smoking. Nicotine in the brain causes a short period of increased alertness and concentration. This shows that although nicotine does not directly cause cancer, it is highly addictive.
(2) Psychological dependence. Psychological or emotional factors such as tension, boredom, anxiety, or excitement can easily make people want to smoke. Special scenes or occasions such as meditation, writing, getting up, and after meals will rely on smoking, and over time, it becomes a habit.
(3) Social factors. Social factors are an external influence, such as mutual recognition and encouragement of smoking in social activities, strong promotion by smokers, the transmission of wrong messages about smoking by the media, and the impact of elder smoking on juniors. Oncoming cigarettes will also challenge quitters. The will and so on.
For smokers who are not addicted or have a low level of tobacco dependence, they can quit smoking with perseverance, but often need to give short-term smoking cessation advice and stimulate their motivation to quit; for those who have a high level of tobacco dependence, they often need to give stronger cessation interventions In order to eventually quit smoking, such as smoking cessation drugs.
Valencline tartrate
At present, the smoking cessation drugs that have been approved for use in our country are: bupropion hydrochloride and varenicline tartrate.
Valenclinic tartrate is a new type of non-nicotine quit smoking drug, which has a high affinity and selectivity for α4β2 nicotine acetylcholine receptors in neurons. effect. Varenicline and nicotine acetylcholine receptors combine to act as an agonist, stimulating the release of dopamine, and help to alleviate tobacco cravings and various withdrawal symptoms after smoking cessation; meanwhile, its antagonistic properties can prevent nicotine and receptor The combination of reducing the pleasure of smoking and reducing the urge to smoke, thereby reducing the possibility of relapse.
